ArticleThe Journal of experimental medicine2003
Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 190 citations in OpenAlex.
- Identification of distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation.bioRxiv : the preprint server for biology · 2025Article
- Article
- Article
- Topical application of a CCL22-binding aptamer suppresses contact allergy.Molecular therapy. Nucleic acids · 2024Article
- The Evolving Role of Dendritic Cells in Atherosclerosis.International journal of molecular sciences · 2024Review
- Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis.Nature cardiovascular research · 2024Article
- Immune cell-mediated features of atherosclerosis.Frontiers in cardiovascular medicine · 2024Review
- Rapid protection against viral infections by chemokine-accelerated post-exposure vaccination.Frontiers in immunology · 2024Article
- TRPV4 differentially controls inflammatory cytokine networks during static and dynamic compression of the intervertebral disc.JOR spine · 2023Article
- Tumor eradication by hetIL-15 locoregional therapy correlates with an induced intratumoral CD103Cell reports · 2023Article
- CCL17 Protects Against Viral Myocarditis by Suppressing the Recruitment of Regulatory T Cells.Journal of the American Heart Association · 2023Article
- CC Chemokine Receptor 4 (CCR4) as a Possible New Target for Therapy.International journal of molecular sciences · 2022Review
- CCL17 acts as a novel therapeutic target in pathological cardiac hypertrophy and heart failure.The Journal of experimental medicine · 2022Article
- CCL17 Aggravates Myocardial Injury by Suppressing Recruitment of Regulatory T Cells.Circulation · 2022Article
- The roles of chemokines following intracerebral hemorrhage in animal models and humans.Frontiers in molecular neuroscience · 2022Review
- Invariant NKT Cells Promote the Development of Highly Cytotoxic Multipotent CXCR3Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- CCL17-expressing dendritic cells in the intestine are preferentially infected by Salmonella but CCL17 plays a redundant role in systemic dissemination.Immunity, inflammation and disease · 2021Article
- Chemokines in Severe Cutaneous Adverse Reactions (SCARs).Biomolecules · 2021Review
- What does elevated TARC/CCL17 expression tell us about eosinophilic disorders?Seminars in immunopathology · 2021Review
- CCL17-producing cDC2s are essential in end-stage lupus nephritis and averted by a parasitic infection.The Journal of clinical investigation · 2021Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells (DCs)(*) fulfill an important regulatory function at the interface of the innate and adaptive immune system. The thymus and activation-regulated chemokine (TARC/CCL17) is produced by DCs and facilitates the attraction of activated T cells. Using a fluorescence-based in vivo reporter system, we show that CCL17 expression in mice is found in activated Langerhans cells and mature DCs located in various lymphoid and nonlymphoid organs, and is up-regulated after stimulation with Toll-like receptor ligands. DCs expressing CCL17 belong to the CD11b(+)CD8(-)Dec205(+) DC subset, including the myeloid-related DCs located in the subepithelial dome of Peyer's patches. CCL17-deficient mice mount diminished T cell-dependent contact hypersensitivity responses and display a deficiency in rejection of allogeneic organ transplants. In contrast to lymphoid organs located at external barriers of the skin and mucosa, CCL17 is not expressed in the spleen, even after systemic microbial challenge or after in vitro stimulation. These findings indicate that CCL17 production is a hallmark of local DC stimulation in peripheral organs but is absent from the spleen as a filter of blood-borne antigens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.