ArticleThe Journal of experimental medicine2003
Flt3 ligand-treated neonatal mice have increased innate immunity against intracellular pathogens and efficiently control virus infections.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 68 citations in OpenAlex.
- The immunoreactive signature of monocyte-derived dendritic cells from patients with Down syndrome.Clinical and experimental immunology · 2024Article
- Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice.Nature communications · 2021Article
- Article
- Flt3 ligand treatment reduces enterovirus A71 lethality in mice with enhanced B cell responses.Scientific reports · 2018Article
- Understanding the Functional Properties of Neonatal Dendritic Cells: A Doorway to Enhance Vaccine Effectiveness?Frontiers in immunology · 2018Review
- Unique aspects of the perinatal immune system.Nature reviews. Immunology · 2017Review
- IL-12p40/IL-10 Producing preCD8α/Clec9A+ Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection.PLoS pathogens · 2016Article
- Age-dependent myeloid dendritic cell responses mediate resistance to la crosse virus-induced neurological disease.Journal of virology · 2014Article
- The immunologic basis for severe neonatal herpes disease and potential strategies for therapeutic intervention.Clinical & developmental immunology · 2013Review
- Functional limitations of plasmacytoid dendritic cells limit type I interferon, T cell responses and virus control in early life.PloS one · 2013Article
- Nodular inflammatory foci are sites of T cell priming and control of murine cytomegalovirus infection in the neonatal lung.PLoS pathogens · 2013Article
- Novel vaccine development strategies for inducing mucosal immunity.Expert review of vaccines · 2012Review
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- Article
- A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature nasopharyngeal-associated lymphoreticular tissue dendritic cell migration.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Serum FLT-3 ligand in a busulphan-induced model of chronic bone marrow hypoplasia in the female CD-1 mouse.International journal of experimental pathology · 2008Article
- Effects of DNA- and Mycobacterium bovis BCG-based delivery of the Flt3 ligand on protective immunity to Mycobacterium tuberculosis.Infection and immunity · 2007Article
- Protracted course of lymphocytic choriomeningitis virus WE infection in early life: induction but limited expansion of CD8+ effector T cells and absence of memory CD8+ T cells.Journal of virology · 2007Article
- Type I interferons protect neonates from acute inflammation through interleukin 10-producing B cells.The Journal of experimental medicine · 2007Article
- Induction of protective immunity to Listeria monocytogenes in neonates.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flt-3 ligand (FL), a hematopoetic growth factor, increases the number of dendritic cells (DCs), B cells, and natural killer cells in adult mice but the effect in neonates was unknown. We show that FL treatment of newborn mice induced a >100-fold increase in the innate resistance against infection with herpes simplex virus type 1 and Listeria monocytogenes. This resistance required interferon (IFN)-alpha/beta for viral and interleukin (IL)-12 for bacterial infections. Long-term survival after viral but not bacterial infection was increased approximately 100-fold by FL treatment. After treatment, CD11c(+)/major histocompatibility complex type II(+) and CD11c(+)/B220(+) DC lineage cells were the only cell populations increased in the spleen, liver, peritoneum, and skin. DC induction was independent of IFNs, IL-2, -4, -7, -9, -15, and mature T and B cells. The data suggest that FL increases the number of DCs in neonates and possibly in other immune-compromised individuals, which in turn improves IFN-alpha/beta- and IL-12-associated immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.