ArticleArteriosclerosis, thrombosis, and vascular biology2003
Suppression subtractive hybridization identifies distinctive expression markers for coronary and internal mammary arteries.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- T-cadherin as a potential novel regulator of intestinal inflammation and fibrosis.Frontiers in physiology · 2026Review
- Resilience of the Internal Mammary Artery to Atherogenesis: Shifting From Risk to Resistance to Address Unmet Needs.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Comparative gene array analyses of severe elastic fiber defects in late embryonic and newborn mouse aorta.Physiological genomics · 2018Article
- Smooth muscle cell fate and plasticity in atherosclerosis.Cardiovascular research · 2018Review
- Identification of differentially expressed genes of Trichinella spiralis larvae after exposure to host intestine milieu.PloS one · 2013Article
- Development of an eight gene expression profile implicating human breast tumours of all grade.Molecular biology reports · 2012Article
- Exercise does not attenuate early CAD progression in a pig model.Medicine and science in sports and exercise · 2012Article
- Profiling of differentially expressed genes using suppression subtractive hybridization in an equine model of chronic asthma.PloS one · 2012Article
- Advances in tenascin-C biology.Cellular and molecular life sciences : CMLS · 2011Review
- Pleiotrophin (PTN) is expressed in vascularized human atherosclerotic plaques: IFN-{gamma}/JAK/STAT1 signaling is critical for the expression of PTN in macrophages.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Adiponectin action from head to toe.Endocrine · 2010Review
- Differential gene expression during compensatory sprouting of dendrites in the auditory system of the cricket Gryllus bimaculatus.Insect molecular biology · 2009Article
- Proliferative capacity of vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis.Journal of vascular surgery · 2009Article
- Adiponectin receptors, with special focus on the role of the third receptor, T-cadherin, in vascular disease.Medical molecular morphology · 2007Review
- Creation, validation, and quantitative analysis of protein expression in vascular tissue microarrays.Cardiovascular pathology : the official journal of the Society for Cardiovascular PathologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe sought to identify differentially expressed genes in the athero-prone coronary artery and athero-resistant internal mammary arteries. METHODS AND
resultsUsing suppressive subtraction hybridization, we generated reciprocal cDNA collections of representative mRNAs specific to porcine coronary arteries versus porcine mammary arteries. We screened 1000 suppressive subtraction hybridization cDNA clones by dot blot array and sequenced 600 of those showing the most marked expression differences. Northern blot, in situ hybridization, and immunostaining confirmed the differential gene expression patterns identified by the dot blot arrays. Genes associated with mammary arteries included claudin-10 and h-cadherin, which are genes associated with tight junctions and intermediate junctions. In contrast, genes associated with proatherosclerotic processes, such as lipid retention and metabolism, inflammation, and cell growth, were preferentially expressed in coronary arteries.
conclusionsNormal coronary arteries have gene expression program that is significantly different than internal mammary arteries. These differences may partly explain the resistance of coronary arteries and internal mammary arteries to atherosclerosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.