ArticleThe Biochemical journal2003
Increased expression of the lipocalin 24p3 as an apoptotic mechanism for MK886.
Article in The Biochemical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 48 citations in OpenAlex.
- Antidepressant Effects of Ginsenoside Rc on L-Alpha-Aminoadipic Acid-Induced Astrocytic Ablation and Neuroinflammation in Mice.International journal of molecular sciences · 2024Article
- Antimicrobial Activity of Mesenchymal Stem Cells: Current Status and New Perspectives of Antimicrobial Peptide-Based Therapies.Frontiers in immunology · 2017Review
- Serum lipocalin-2 levels positively correlate with coronary artery disease and metabolic syndrome.Cardiovascular diabetology · 2013Article
- Small lipid-binding proteins in regulating endothelial and vascular functions: focusing on adipocyte fatty acid binding protein and lipocalin-2.British journal of pharmacology · 2012Review
- Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration.Journal of neuroinflammation · 2011Article
- Lipocalin-2-induced cytokine production enhances endometrial carcinoma cell survival and migration.International journal of biological sciences · 2011Article
- Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin.Medical oncology (Northwood, London, England) · 2010Article
- MK886-induced apoptosis depends on the 5-LO expression level in human malignant glioma cells.Journal of neuro-oncology · 2010Article
- Laser capture microdissection and genetic analysis of carbon-labeled Kupffer cells.World journal of gastroenterology · 2009Article
- Lipocalin-2 is an autocrine mediator of reactive astrocytosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Mouse 24p3 protein has an effect on L929 cell viability.International journal of biological sciences · 2007Article
- Neutrophil gelatinase-associated lipocalin as a survival factor.The Biochemical journal · 2005Article
- Expression pattern and regulation of genes differ between fibroblasts of adhesion and normal human peritoneum.Reproductive biology and endocrinology : RB&E · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
MK886, a strong proapoptotic agent, is an inhibitor of 5-lipoxygenase (LOX) through binding to the 5-LOX-activating protein (FLAP). Although MK886-induced apoptosis is through a FLAP-independent pathway, the precise mechanisms are not understood. In the present study, a possible role of 24p3, a lipocalin, in MK886-induced apoptosis was investigated. Exposure of murine prolymphoid progenitor cells (FL5.12) to 20 microM MK886 for 16 h dramatically increased 24p3 mRNA and protein expression. Induction could also be achieved with another FLAP inhibitor, MK591. The induction of 24p3 by MK886 was dose- and time-dependent. The up-regulated 24p3 mRNA expression by MK886 was enhanced a further 3.1-fold by WY14643, an activator of peroxisome-proliferator-activated receptor alpha, whereas ciglitazone, an activator of peroxisome-proliferator-activated receptor gamma attenuated the MK886-induced 24p3 expression by more than 50%. Neither WY14643 nor ciglitazone alone had any effect on the expression of 24p3. The induction of 24p3 by MK886 was dependent on the synthesis of new protein(s), since cycloheximide, an inhibitor of protein synthesis, prevented this effect. In all cases, including the inhibition of MK886-induced 24p3 protein expression by stable transfection with antisense cDNA of 24p3, the extent of apoptosis closely paralleled 24p3 levels. Apoptosis induced by MK886, or enhanced by WY14643, was accompanied by the cleavage and activation of caspase-3. The overexpression of bcl-2 or bcl-x(L) in FL5.12 cells inhibited apoptosis induced by MK886 as well as the enhancement of apoptosis by WY14643. Thus 24p3 is an MK886-inducible gene and may play an important role in MK886-induced apoptosis.
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Registered trials
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