ArticleAmerican journal of human genetics2003
Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 4 of them syntheses that pooled it.
What it found
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Who cites it
51 citing papers in PubMed, 4 syntheses or guidelines pooled it, 179 citations in OpenAlex.
- Meta-Analysis of the COMT Val158Met Polymorphism in Major Depressive Disorder: Effect of Ethnicity.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Pooled it
- Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes.European journal of human genetics : EJHG · 2012Pooled it
- Meta-analysis of genome-wide association studies for personality.Molecular psychiatry · 2012Pooled it
- Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity.Molecular psychiatry · 2010Pooled it
- Hunting for Genes Underlying Emotionality in the Laboratory Rat: Maps, Tools and Traps.Current neuropharmacology · 2023Review
- Genetic Basis of Dual Diagnosis: A Review of Genome-Wide Association Studies (GWAS) Focusing on Patients with Mood or Anxiety Disorders and Co-Occurring Alcohol-Use Disorders.Diagnostics (Basel, Switzerland) · 2021Review
- Genetic Architecture of Depression: Where Do We Stand Now?Advances in experimental medicine and biology · 2021Article
- Review
- Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co-occurring traits.Genes, brain, and behavior · 2018Article
- The genetics of human personality.Genes, brain, and behavior · 2018Review
- Identification of eQTLs for hepatic Xbp1s and Socs3 gene expression in mice fed a high-fat, high-caloric diet.G3 (Bethesda, Md.) · 2015Article
- Prenatal diagnosis of complete maternal uniparental isodisomy of chromosome 4 in a fetus without congenital abnormality or inherited disease-associated variations.Molecular cytogenetics · 2015Article
- A genome-wide linkage study of individuals with high scores on NEO personality traits.Molecular psychiatry · 2012Article
- Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion.Translational psychiatry · 2012Article
- TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies.Molecular psychiatry · 2011Article
- Overview of the genetics of major depressive disorder.Current psychiatry reports · 2010Review
- Article
- Genome-wide association scan for five major dimensions of personality.Molecular psychiatry · 2010Article
- ADH1A variation predisposes to personality traits and substance dependence.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- The genetics of major depression: moving beyond the monoamine hypothesis.The Psychiatric clinics of North America · 2010Review
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
Several theoretical studies have suggested that large samples of randomly ascertained siblings can be used to ascertain phenotypically extreme individuals and thereby increase power to detect genetic linkage in complex traits. Here, we report a genetic linkage scan using extremely discordant and concordant sibling pairs, selected from 34,580 sibling pairs in the southwest of England who completed a personality questionnaire. We performed a genomewide scan for quantitative-trait loci (QTLs) that influence variation in the personality trait of neuroticism, or emotional stability, and we established genomewide empirical significance thresholds by simulation. The maximum pointwise P values, expressed as the negative logarithm (base 10), were found on 1q (3.95), 4q (3.84), 7p (3.90), 12q (4.74), and 13q (3.81). These five loci met or exceeded the 5% genomewide significance threshold of 3.8 (negative logarithm of the P value). QTLs on chromosomes 1, 12, and 13 are likely to be female specific. One locus, on chromosome 1, is syntenic with that reported from QTL mapping of rodent emotionality, an animal model of neuroticism, suggesting that some animal and human QTLs influencing emotional stability may be homologous.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.