ArticleMolecular and cellular biology2003
Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- The differentiation state of the Schwann cell progenitor drives phenotypic variation between two contagious cancers.PLoS pathogens · 2021Article
- Satellite glial cells promote regenerative growth in sensory neurons.Nature communications · 2020Article
- KIR2DL5 mutation and loss underlies sporadic dermal neurofibroma pathogenesis and growth.Oncotarget · 2017Article
- Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling.Brain : a journal of neurology · 2014Article
- Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors.BMC medicine · 2013Article
- The spatial and temporal arrangement of the radial glial scaffold suggests a role in axon tract formation in the developing spinal cord.Journal of anatomy · 2013Article
- β-1,4-Galactosyltransferase-involved in lipopolysaccharide-induced adhesion of Schwann cells.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2011Article
- Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene.EMBO molecular medicine · 2009Article
- Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential.Cell stem cell · 2008Article
- Reactive changes of retinal astrocytes and Müller glial cells in kainate-induced neuroexcitotoxicity.Journal of anatomy · 2007Article
- Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma.The American journal of pathology · 2006Article
- Article
- Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells.Genes & development · 2005Article
- Differential modulation of malignant peripheral nerve sheath tumor growth by omega-3 and omega-6 fatty acids.Oncogene · 2005Article
- Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis.Cancer cell · 2005Article
- Mechanisms and roles of axon-Schwann cell interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Review
- Transcriptional profiling in an MPNST-derived cell line and normal human Schwann cells.Neuron glia biology · 2004Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Loss of axonal contact characterizes Schwann cells in benign and malignant peripheral nerve sheath tumors (MPNST) from neurofibromatosis type 1 (NF1) patients. Tumor Schwann cells demonstrate NF1 mutations, elevated Ras activity, and aberrant epidermal growth factor receptor (EGFR) expression. Using cDNA microarrays, we found that brain lipid binding protein (BLBP) is elevated in an EGFR-positive subpopulation of Nf1 mutant mouse Schwann cells (Nf1(-/-) TXF) that grows away from axons; BLBP expression was not affected by farnesyltransferase inhibitor, an inhibitor of H-Ras. BLBP was also detected in EGFR-positive cell lines derived from Nf1:p53 double mutant mice and human MPNST. BLBP expression was induced in normal Schwann cells following transfection with EGFR but not H-Ras12V. Furthermore, EGFR-mediated BLBP expression was not inhibited by dominant-negative H-Ras, indicating that BLBP expression is downstream of Ras-independent EGFR signaling. BLBP-blocking antibodies enabled process outgrowth from Nf1(-/-) TXF cells and restored interaction with axons, without affecting cell proliferation or migration. Following injury, BLBP expression was induced in normal sciatic nerves when nonmyelinating Schwann cells remodeled their processes. These data suggest that BLBP, stimulated by Ras-independent pathways, regulates Schwann cell-axon interactions in normal peripheral nerve and peripheral nerve tumors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.