ArticleMolecular and cellular biology2003
Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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Who cites it
38 citing papers in PubMed.
- Androgen receptor monomers and dimers regulate opposing biological processes in prostate cancer cells.Nature communications · 2024Article
- Cryo-EM reveals the architecture of the PELP1-WDR18 molecular scaffold.Nature communications · 2022Article
- N/C Interactions Are Dispensable for Normal In Vivo Functioning of the Androgen Receptor in Male Mice.Endocrinology · 2022Article
- The challenges of androgen insensitivity syndrome.Archives of medical science : AMS · 2022Article
- Computer-Aided Ligand Discovery for Estrogen Receptor Alpha.International journal of molecular sciences · 2020Review
- Modulation of androgen receptor DNA binding activity through direct interaction with the ETS transcription factor ERG.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- GR Utilizes a Co-Chaperone Cytoplasmic CAR Retention Protein to Form an N/C Interaction.Nuclear receptor signaling · 2018Article
- Binding of bisphenol A, bisphenol AF, and bisphenol S on the androgen receptor: Coregulator recruitment and stimulation of potential interaction sites.Toxicology in vitro : an international journal published in association with BIBRA · 2017Article
- Androgen receptor regulation by histone methyltransferase Suppressor of variegation 3-9 homolog 2 and Melanoma antigen-A11.Molecular and cellular endocrinology · 2017Article
- Three novel and two known androgen receptor gene mutations associated with androgen insensitivity syndrome in sex-reversed XY female patients.Journal of genetics · 2016Article
- Post-translational Down-regulation of Melanoma Antigen-A11 (MAGE-A11) by Human p14-ARF Tumor Suppressor.The Journal of biological chemistry · 2015Article
- Endostatin: A novel inhibitor of androgen receptor function in prostate cancer.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Synthesis of a tetrasubstituted tetrahydronaphthalene scaffold for α-helix mimicry via a MgBr2-catalyzed Friedel-Crafts epoxide cycloalkylation.Organic letters · 2013Article
- Melanoma antigen-A11 (MAGE-A11) enhances transcriptional activity by linking androgen receptor dimers.The Journal of biological chemistry · 2013Article
- Structural features discriminate androgen receptor N/C terminal and coactivator interactions.Molecular and cellular endocrinology · 2012Review
- Gain in transcriptional activity by primate-specific coevolution of melanoma antigen-A11 and its interaction site in androgen receptor.The Journal of biological chemistry · 2011Article
- Analysis of interdomain interactions of the androgen receptor.Methods in molecular biology (Clifton, N.J.) · 2011Article
- CCAAT/Enhancer-binding protein beta DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CREB-binding protein (CBP).The Journal of biological chemistry · 2010Article
- Transcriptional synergy between melanoma antigen gene protein-A11 (MAGE-11) and p300 in androgen receptor signaling.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Coactivator recruitment by activation function 2 (AF2) in the steroid receptor ligand binding domain takes place through binding of an LXXLL amphipathic alpha-helical motif at the AF2 hydrophobic surface. The androgen receptor (AR) and certain AR coregulators are distinguished by an FXXLF motif that interacts selectively with the AR AF2 site. Here we show that LXXLL and FXXLF motif interactions with steroid receptors are modulated by oppositely charged residues flanking the motifs and charge clusters bordering AF2 in the ligand binding domain. An increased number of charged residues flanking AF2 in the ligand binding domain complement the two previously characterized charge clamp residues in coactivator recruitment. The data suggest a model whereby coactivator recruitment to the receptor AF2 surface is initiated by complementary charge interactions that reflect a reversal of the acidic activation domain-coactivator interaction model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.