ArticleMolecular and cellular biology2003
RNA polymerase II accumulation in the promoter-proximal region of the dihydrofolate reductase and gamma-actin genes.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 81 citations in OpenAlex.
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- Modulation of the Host Nuclear Compartment byFrontiers in cellular and infection microbiology · 2021Article
- Elongin C Contributes to RNA Polymerase II Degradation by the Interferon Antagonist NSs of La Crosse Orthobunyavirus.Journal of virology · 2020Article
- Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells.Cancers · 2020Review
- Gene regulation of mammalian long non-coding RNA.Molecular genetics and genomics : MGG · 2018Review
- BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation.Cell reports · 2018Article
- Article
- Kisspeptin Induces Dynamic Chromatin Modifications to Control GnRH Gene Expression.Molecular neurobiology · 2016Article
- Context-dependent modulation of Pol II CTD phosphatase SSUP-72 regulates alternative polyadenylation in neuronal development.Genes & development · 2015Article
- The Core Promoter and Redox-sensitiveJournal of nature and science · 2015Article
- Temporal Dissection of Rate Limiting Transcriptional Events Using Pol II ChIP and RNA Analysis of Adrenergic Stress Gene Activation.PloS one · 2015Article
- Diversity of two forms of DNA methylation in the brain.Frontiers in genetics · 2014Article
- Large-scale chromatin immunoprecipitation with promoter sequence microarray analysis of the interaction of the NSs protein of Rift Valley fever virus with regulatory DNA regions of the host genome.Journal of virology · 2012Article
- Article
- Interferon antagonist NSs of La Crosse virus triggers a DNA damage response-like degradation of transcribing RNA polymerase II.The Journal of biological chemistry · 2011Article
- The Transition of Poised RNA Polymerase II to an Actively Elongating State Is a "Complex" Affair.Genetics research international · 2011Article
- HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter.Journal of biomedicine & biotechnology · 2011Article
- RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription.Nucleic acids research · 2010Article
- Synergistic action of RNA polymerases in overcoming the nucleosomal barrier.Nature structural & molecular biology · 2010Article
- Yin Yang 1 is a critical repressor of matrix metalloproteinase-9 expression in brain neurons.The Journal of biological chemistry · 2008Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The carboxyl-terminal domain (CTD) of RNA polymerase II (Pol II) can be phosphorylated at serine 2 (Ser-2) and serine 5 (Ser-5) of the CTD heptad repeat YSPTSPS, and this phosphorylation is important in coupling transcription to RNA processing, including 5' capping, splicing, and polyadenylation. The mammalian endogenous dihydrofolate reductase and gamma-actin genes have been used to study the association of Pol II with different regions of transcribed genes (promoter-proximal compared to distal regions) and the phosphorylation status of its CTD. For both genes, Pol II is more concentrated in the promoter-proximal regions than in the interior regions. Moreover, different phosphorylation forms of Pol II are associated with distinct regions. Ser-5 phosphorylation of Pol II is concentrated near the promoter, while Ser-2 phosphorylation is observed throughout the gene. These results suggest that the accumulation of paused Pol II in promoter-proximal regions may be a common feature of gene regulation in mammalian cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.