ArticleThe Journal of physiology2003
A novel signalling pathway originating in mitochondria modulates rat skeletal muscle membrane excitability.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Cardiac autonomic responses and number of repetitions maximum after LED irradiation in the ipsilateral and contralateral lower limb.Lasers in medical science · 2018Trial
- Effect of 830 nm low-level laser therapy in exercise-induced skeletal muscle fatigue in humans.Lasers in medical science · 2009Trial
- Exercise and fatigue: integrating the role of KEuropean journal of applied physiology · 2023Review
- Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress.JCI insight · 2022Article
- Regulation of muscle potassium: exercise performance, fatigue and health implications.European journal of applied physiology · 2021Review
- Calcium Fluxes in Work-Related Muscle Disorder: Implications from a Rat Model.BioMed research international · 2019Article
- Thermal pretreatment facilitates recovery from prolonged low-frequency force depression in rat fast-twitch muscle.Physiological reports · 2018Article
- NHE- and diffusion-dependent proton fluxes across the tubular system membranes of fast-twitch muscle fibers of the rat.The Journal of general physiology · 2018Article
- Mechanical isolation, and measurement of force and myoplasmic free [CaNature protocols · 2017Article
- Longitudinal and transversal propagation of excitation along the tubular system of rat fast-twitch muscle fibres studied by high speed confocal microscopy.The Journal of physiology · 2012Article
- Modulation of contractile apparatus Ca2+ sensitivity and disruption of excitation-contraction coupling by S-nitrosoglutathione in rat muscle fibres.The Journal of physiology · 2011Article
- Carbohydrate administration and exercise performance: what are the potential mechanisms involved?Sports medicine (Auckland, N.Z.) · 2010Review
- Distinct effects of subcellular glycogen localization on tetanic relaxation time and endurance in mechanically skinned rat skeletal muscle fibres.The Journal of physiology · 2009Article
- Do multiple ionic interactions contribute to skeletal muscle fatigue?The Journal of physiology · 2008Review
- Effect of mitochondria poisoning by FCCP on Ca2+ signaling in mouse skeletal muscle fibers.Pflugers Archiv : European journal of physiology · 2008Article
- Tubular system excitability: an essential component of excitation-contraction coupling in fast-twitch fibres of vertebrate skeletal muscle.Journal of muscle research and cell motility · 2006Review
- Mitochondrial redox state and Ca2+ sparks in permeabilized mammalian skeletal muscle.The Journal of physiology · 2005Article
- Effects of ADP on action potential-induced force responses in mechanically skinned rat fast-twitch fibres.The Journal of physiology · 2004Article
- Excitability of the T-tubular system in rat skeletal muscle: roles of K+ and Na+ gradients and Na+-K+ pump activity.The Journal of physiology · 2004Article
- Osmotic properties of the sealed tubular system of toad and rat skeletal muscle.The Journal of general physiology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single skeletal muscle fibres from rat and cane toad were mechanically skinned and stimulated either electrically by initiating action potentials in the sealed transverse (t-) tubular system or by ion substitution causing depolarisation of the t-system to pre-determined levels. Depression of mitochondrial ATP-producing function with three diverse mitochondrial function antagonists (azide: 1-10 mM; oligomycin 1 microg ml-1 and carbonyl cyanide 4-trifluoromethoxyphenylhydrazone (FCCP) 1 microM), under conditions in which the cytosolic ATP was maintained high and constant, invariably reduced the excitability of rat fibres but had no obvious effect on the excitability of toad fibres, where mitochondria are less abundant and differently located. The reduction in excitability linked to mitochondria in rat fibres appears to be caused by depolarisation of the sealed t-system membrane. These observations suggest that mitochondria can regulate the functional state of mammalian muscle cells and have important implications for understanding how the balance between ATP utilisation and ATP production is regulated at the cellular level in general and in mammalian skeletal muscle fibres in particular.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.