ArticleJournal of cellular and molecular medicine
Dantrolene protects neurons against kainic acid induced apoptosis in vitro and in vivo.
Article in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Intranasal Dantrolene Nanoparticles for Treatment of Amyotrophic Lateral Sclerosis as a Disease-Modifying Drug.bioRxiv : the preprint server for biology · 2025Article
- Neuronal microRNAs safeguard ER CaCellular and molecular life sciences : CMLS · 2022Article
- Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice.Human molecular genetics · 2016Article
- Ryanodine receptors: physiological function and deregulation in Alzheimer disease.Molecular neurodegeneration · 2014Review
- Transcriptome profiling of hippocampal CA1 after early-life seizure-induced preconditioning may elucidate new genetic therapies for epilepsy.The European journal of neuroscience · 2013Article
- Nanospaces between endoplasmic reticulum and mitochondria as control centres of pancreatic β-cell metabolism and survival.Protoplasma · 2012Review
- Dantrolene is neuroprotective in Huntington's disease transgenic mouse model.Molecular neurodegeneration · 2011Article
- Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strains.Experimental eye research · 2011Article
- Effects of dantrolene on apoptosis and immunohistochemical expression of NeuN in the spinal cord after traumatic injury in rats.International journal of experimental pathology · 2010Article
- The cytoprotective effects of dantrolene: a ryanodine receptor antagonist.Anesthesia and analgesia · 2010Review
- Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes.Cell death & disease · 2010Article
- Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Excitatory and inhibitory synaptic transmission is differentially influenced by two ortho-substituted polychlorinated biphenyls in the hippocampal slice preparation.Toxicology and applied pharmacology · 2009Article
- Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit.Neurocritical care · 2009Review
- Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Computational models of neuronal biophysics and the characterization of potential neuropharmacological targets.Current medicinal chemistry · 2008Review
- Inflammatory mechanisms associated with brain damage induced by kainic acid with special reference to the interleukin-1 system.Journal of cellular and molecular medicineReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apoptotic cell death induced by kainic acid (KA) in cultures of rat cerebellar granule cells (CGC) and in different brain regions of Wistar rat pups on postnatal day 21 (P21) was studied. In vitro, KA (100-500 microM) induced a concentration-dependent loss of cell viability in MTT assay and cell death had apoptotic morphology as studied by chromatin staining with propidium iodide (PI). In vivo, twenty-four hours after induction of status epilepticus (SE) by an intraperitoneal KA injection (5 mg/kg) we quantified apoptotic cells in hippocampus (CA1 and CA3), parietal cortex and cerebellum using PI staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) technique. We report that dantrolene, a specific ryanodine receptor antagonist, was able to significantly reduce the apoptotic cell death in CGC cultures and in hyppocampal CA1 and parietal cortex regions. Our finding can be valuable for neuroprotective therapy strategies in patients with repeated generalized seizures or status epilepticus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.