ArticleAmerican journal of human genetics2003
On the identification of disease mutations by the analysis of haplotype similarity and goodness of fit.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed.
- Information Theory in Computational Biology: Where We Stand Today.Entropy (Basel, Switzerland) · 2020Article
- Statistical Method Based on Bayes-Type Empirical Score Test for Assessing Genetic Association with Multilocus Genotype Data.International journal of genomics · 2020Article
- Structured Genome-Wide Association Studies with Bayesian Hierarchical Variable Selection.Genetics · 2019Article
- Multisample adjusted U-statistics that account for confounding covariates.Statistics in medicine · 2018Article
- A comparison of genomic profiles of complex diseases under different models.BMC medical genomics · 2016Article
- Multiple SNP Set Analysis for Genome-Wide Association Studies Through Bayesian Latent Variable Selection.Genetic epidemiology · 2015Article
- A multi-SNP association test for complex diseases incorporating an optimal P-value threshold algorithm in nuclear families.BMC genomics · 2015Article
- Assessing gene-environment interactions for common and rare variants with binary traits using gene-trait similarity regression.Genetics · 2015Article
- Imputation without doing imputation: a new method for the detection of non-genotyped causal variants.Genetic epidemiology · 2014Article
- GENE-LEVEL PHARMACOGENETIC ANALYSIS ON SURVIVAL OUTCOMES USING GENE-TRAIT SIMILARITY REGRESSION.The annals of applied statistics · 2014Article
- Analysis of gene-gene interactions using gene-trait similarity regression.Human heredity · 2014Article
- Haplotype kernel association test as a powerful method to identify chromosomal regions harboring uncommon causal variants.Genetic epidemiology · 2013Article
- Recursive organizer (ROR): an analytic framework for sequence-based association analysis.Human genetics · 2013Article
- SBERIA: set-based gene-environment interaction test for rare and common variants in complex diseases.Genetic epidemiology · 2013Article
- Case-Control Genome-wide Joint Association Study Using Semiparametric Empirical Model and Approximate Bayes Factor.Journal of statistical computation and simulation · 2013Article
- Genetic association studies: an information content perspective.Current genomics · 2012Article
- Haplotype-based methods for detecting uncommon causal variants with common SNPs.Genetic epidemiology · 2012Article
- Similarity-based multimarker association tests for continuous traits.Annals of human genetics · 2012Article
- Article
- Detecting rare functional variants using a wavelet-based test on quantitative and qualitative traits.BMC proceedings · 2011Article
4 more citing papers are in PubMed but not listed here.
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4 authors.
Funding
Abstract
The observation that haplotypes from a particular region of the genome differ between affected and unaffected individuals or between chromosomes transmitted to affected individuals versus those not transmitted is sound evidence for a disease-liability mutation in the region. Tests for differentiation of haplotype distributions often take the form of either Pearson's chi(2) statistic or tests based on the similarity among haplotypes in the different populations. In this article, we show that many measures of haplotype similarity can be expressed in the same quadratic form, and we give the general form of the variance. As we describe, these methods can be applied to either phase-known or phase-unknown data. We investigate the performance of Pearson's chi(2) statistic and haplotype similarity tests through use of evolutionary simulations. We show that both approaches can be powerful, but under quite different conditions. Moreover, we show that the power of both approaches can be enhanced by clustering rare haplotypes from the distributions before performing a test.
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