ArticleEuropean journal of clinical pharmacology2003
Determinants for drug prescribing to children below the minimum licensed age.
Article in European journal of clinical pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 33 citations in OpenAlex.
- Younger Children with Respiratory Tract Infections Are More Exposed to Off-Label Treatments: An Exploratory Retrospective Study in a Pediatric Emergency Setting.Children (Basel, Switzerland) · 2024Article
- Medicine manipulation: An alternative to mitigate therapeutic gaps in the Brazilian Unified Health System?PloS one · 2022Article
- The Unlicensed and Off-label Prescription of Medications in General Paediatric Ward: An Observational Study.Current pediatric reviews · 2019Observational
- Two decades of off-label prescribing in children: a literature review.World journal of pediatrics : WJP · 2018Review
- Off-Label Prescribing for Children with Migraines in U.S. Ambulatory Care Settings.Journal of managed care & specialty pharmacy · 2017Article
- Adverse drug reactions and off-label and unlicensed medicines in children: a prospective cohort study of unplanned admissions to a paediatric hospital.British journal of clinical pharmacology · 2014Article
- Off-label and unlicensed medicine use and adverse drug reactions in children: a narrative review of the literature.European journal of clinical pharmacology · 2012Review
- Clinical trials research in pediatrics: strategies for effective collaboration between investigator sites and the pharmaceutical industry.Paediatric drugs · 2006Article
- A literature review on off-label drug use in children.European journal of pediatrics · 2005Review
- [Drug prescriptions study in the outpatient setting: assessment of off-label uses in children].Atencion primariaArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIn the light of the undesired effects that unlicensed and off-label drug use might have, it is necessary to study the determinants affecting the prescribing of such drugs. Prescription of drugs to children younger than the minimum licensed age may carry the highest risk of adverse reactions. To obtain insight into the factors that affect prescription of drugs to children below the minimum licensed age, we conducted a population-based case-control study.
methodsThe case-control study was nested in a cohort of 13,426 children aged 0-16 years, who were registered in the Integrated Primary Care Information (IPCI) project, a longitudinal observational general practitioners' database in the Netherlands. "Cases" were children who received a drug prescription for which they were below the minimum licensed age. To each case we matched up to four controls based on GP practice and patient age. As potential risk factors we evaluated the use of health care resources, and acute and chronic morbidity.
resultsWe identified 447 cases who were matched to 1355 controls. The cases consulted their GPs significantly more often during the preceding half year, had more drug prescriptions, and had more specialist referrals than the controls. Respiratory diseases were the most important determinants for the prescription of drugs to children below the minimum licensed age. In adolescents, migraine and other headaches were the most important reasons.
conclusionsThis study showed that children suffering from respiratory disease or migraine have the highest risk of receiving a drug prescription for which the patient is below the minimum licensed age. Regulatory authorities and the pharmaceutical industry should be stimulated to improve the evaluation of drug efficacy and safety in children.
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