Evidence map›Paper›PMID 12609940›Full record

Trial reportBMJ (Clinical research ed.)2003

Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial.

Daksha P Trivedi, Richard Doll, Kay Tee Khaw

2 registry-linked trialsOpen access · greenAbstract readClinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ (Clinical research ed.), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 401 papers, 44 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
401citing papers in PubMed, 44 pooled it
64.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01419743 terminatednot on this mapstarted 2011, after this paper: background citation

Randomized Controlled Trial: The Effects of Vitamin D Supplementation on In-vitro Fertilization Outcomes

TypeobservationalSponsorNorthwestern UniversityRan2011 to 2014Enrolled102ConditionsInfertility, Vitamin D Deficiency
NCT02590614 nacompletednot on this mapstarted 2013, after this paper: background citation

Genetic, Dietary and Environmental Influences on Vitamin D Metabolism

TypeinterventionalSponsorMilton S. Hershey Medical CenterRan2013 to 2019Enrolled412ConditionsVitamin D DeficiencyArms800 IU Vitamin D, Placebo
3 · Its place in the literature

Who cites it

401 citing papers in PubMed, 44 syntheses or guidelines pooled it, 1,276 citations in OpenAlex.

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  8. Effects of intermittent or single high-dose vitamin D supplementation on risk of falls and fractures: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
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  9. Efficacy of vitamin DAgeing research reviews · 2023
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341 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Daksha P TrivediClinical Gerontology Unit, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge CB2 2QQ.
Richard Doll
Kay Tee Khaw
University of Cambridge · GBUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the effect of four monthly vitamin D supplementation on the rate of fractures in men and women aged 65 years and over living in the community.

designRandomised double blind controlled trial of 100 000 IU oral vitamin D3 (cholecalciferol) supplementation or matching placebo every four months over five years. SETTING AND

participants2686 people (2037 men and 649 women) aged 65-85 years living in the general community, recruited from the British doctors register and a general practice register in Suffolk.

main outcome measuresFracture incidence and total mortality by cause.

resultsAfter five years 268 men and women had incident fractures, of whom 147 had fractures in common osteoporotic sites (hip, wrist or forearm, or vertebrae). Relative risks in the vitamin D group compared with the placebo group were 0.78 (95% confidence interval 0.61 to 0.99, P=0.04) for any first fracture and 0.67 (0.48 to 0.93, P=0.02) for first hip, wrist or forearm, or vertebral fracture. 471 participants died. The relative risk for total mortality in the vitamin D group compared with the placebo group was 0.88 (0.74 to 1.06, P=0.18). Findings were consistent in men and women and in doctors and the general practice population.

conclusionFour monthly supplementation with 100 000 IU oral vitamin D may prevent fractures without adverse effects in men and women living in the general community.

Indexed as

Administration, OralAgedAged, 80 and overCalcifediolCholecalciferolDouble-Blind MethodFemaleFractures, BoneHeelHumansIncidenceMaleParathyroid HormoneRisk FactorsUltrasonographyCalcifediolCholecalciferolParathyroid Hormone

Identifiers

PMID12609940
PMCPMC150177
OpenAlexW2096150705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.