ArticleBiophysical journal2003
A rhombohedral phase of lipid containing a membrane fusion intermediate structure.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- The beginning and the end of SNARE-induced membrane fusion.FEBS open bio · 2022Review
- Aspects of Biological Replication and Evolution Independent of the Central Dogma: Insights from Protein-Free Vesicular Transformations and Protein-Mediated Membrane Remodeling.The Journal of membrane biology · 2022Article
- A stalk fluid forming above the transition from the lamellar to the rhombohedral phase of lipid membranes.European biophysics journal : EBJ · 2021Article
- Entry Inhibitors: Efficient Means to Block Viral Infection.The Journal of membrane biology · 2020Review
- Rhombohedral trap for studying molecular oligomerization in membranes: application to daptomycin.Soft matter · 2019Article
- Hypothesis - buttressed rings assemble, clamp, and release SNAREpins for synaptic transmission.FEBS letters · 2017Review
- Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come.Pharmacological reviews · 2016Review
- Comparative Study of the Condensing Effects of Ergosterol and Cholesterol.Biophysical journal · 2016Article
- Calculating Transition Energy Barriers and Characterizing Activation States for Steps of Fusion.Biophysical journal · 2016Article
- Expansion of the fusion stalk and its implication for biological membrane fusion.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Regulation of osteoclasts by membrane-derived lipid mediators.Cellular and molecular life sciences : CMLS · 2013Review
- Composite contact of binary lipid membranes.The European physical journal. E, Soft matter · 2013Article
- Membrane permeability of hydrocarbon-cross-linked peptides.Biophysical journal · 2013Article
- Characterization of new DOPC/DHPC platform for dermal applications.European biophysics journal : EBJ · 2013Article
- Recruitment of a phospholipase C/sphingomyelinase into non-lamellar lipid droplets during hydrolysis of lipid bilayers.Chemistry and physics of lipids · 2013Article
- Importance of the hexagonal lipid phase in biological membrane organization.Frontiers in plant science · 2013Article
- Possible role of IRTKS in Tks5-driven osteoclast fusion.Communicative & integrative biology · 2012Article
- Activation thermodynamics of poly(ethylene glycol)-mediated model membrane fusion support mechanistic models of stalk and pore formation.Biophysical journal · 2012Article
- Energetics of stalk intermediates in membrane fusion are controlled by lipid composition.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Acyl-chain correlation in membrane fusion intermediates: x-ray diffraction from the rhombohedral lipid phase.Biophysical journal · 2012Article
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Authors and funding
2 authors.
Funding
Abstract
We constructed the electron density distribution from the x-ray diffraction of a phase of phospholipid that exhibited rhombohedral symmetry. To determine the phases of the diffraction amplitudes, we first extended the well-known one-dimensional swelling method for planar bilayers to a three-dimensional method applicable to a layered system containing in-plane structures, such as rhombohedral structures. The complete phase determination was accomplished by a combination of the swelling method and Luzzati's pattern recognition method. The constructed electron density distribution showed that in each unit cell, two apposed monolayers merged across the water layer and developed into an hourglass structure consistent with a postulated membrane fusion intermediate state called a stalk. The observation of the stalk structure lends a strong support to the stalk hypothesis for membrane fusion and opens a way to measure the structural parameters in the fusion pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.