ArticleBiophysical journal2003
Plasmon-waveguide resonance and impedance spectroscopy studies of the interaction between penetratin and supported lipid bilayer membranes.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 74 citations in OpenAlex.
- Leaky Coupled Waveguide-Plasmon Modes for Enhanced Light-Matter Interaction.Sensors (Basel, Switzerland) · 2025Article
- Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development.Molecules (Basel, Switzerland) · 2021Review
- Surface plasmon-coupled emission imaging for biological applications.Analytical and bioanalytical chemistry · 2020Review
- Article
- Improved Detection of Plasmon Waveguide Resonance Using Diverging Beam, Liquid Crystal Retarder, and Application to Lipid Orientation Determination.Sensors (Basel, Switzerland) · 2019Article
- Fluorophore labeling of a cell-penetrating peptide significantly alters the mode and degree of biomembrane interaction.Scientific reports · 2018Article
- Cell-penetrating peptide secures an efficient endosomal escape of an intact cargo upon a brief photo-induction.Cellular and molecular life sciences : CMLS · 2013Article
- Investigation of homeodomain membrane translocation properties: insights from the structure determination of engrailed-2 homeodomain in aqueous and membrane-mimetic environments.Biophysical journal · 2013Article
- A comparison of binding surfaces for SPR biosensing using an antibody-antigen system and affinity distribution analysis.Methods (San Diego, Calif.) · 2013Article
- Article
- Distinct behaviour of the homeodomain derived cell penetrating peptide penetratin in interaction with different phospholipids.PloS one · 2010Article
- Alternative mechanisms for the interaction of the cell-penetrating peptides penetratin and the TAT peptide with lipid bilayers.Biophysical journal · 2009Article
- Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives.Pharmaceutical research · 2007Review
- Article
- Plasmon resonance methods in GPCR signaling and other membrane events.Current protein & peptide science · 2005Review
- Penetratin-membrane association: W48/R52/W56 shield the peptide from the aqueous phase.Biophysical journal · 2005Article
- A molecular view on the interaction of the trojan peptide penetratin with the polar interface of lipid bilayers.Biophysical journal · 2004Article
- Graphical analysis of mass and anisotropy changes observed by plasmon-waveguide resonance spectroscopy can provide useful insights into membrane protein function.Biophysical journal · 2004Article
- Charge-dependent translocation of the Trojan peptide penetratin across lipid membranes.Biophysical journal · 2003Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The interaction between the cell-penetrating peptide, penetratin, and solid-supported lipid bilayer membranes consisting of either egg phosphatidylcholine (PC) or a 75/25 mol% mixture of egg PC and palmitoyloleylphosphatidylglycerol has been studied by simultaneously measuring plasmon-waveguide resonance (PWR) spectra and impedance spectra of lipid-peptide mixtures. When penetratin was incorporated into an egg PC + palmitoyloleylphosphatidylglycerol bilayer, PWR measurements showed a hyperbolic increase in the average refractive index and the refractive index anisotropy, with no change in membrane thickness, over a concentration range between 0 and 2 micro M peptide. In the case of an egg PC bilayer, a biphasic dependence was observed, with a decrease in average refractive index and anisotropy and no thickness change occurring between 0 and 5 micro M peptide, and an increase in membrane thickness occurring between 5 and 15 micro M peptide with no further change in the refractive index parameters. For both membranes, the impedance spectroscopy measurements demonstrated that the electrical resistance was not altered by peptide incorporation, whereas a decrease in membrane capacitance occurred with the same concentration dependence as observed in the PWR experiments, although for the PC membrane no further changes in electrical properties were observed in the higher concentration range. A structural interpretation of these results is described, in which the peptide binds electrostatically within the headgroup region of the bilayer and influences the headgroup conformation, amount of bound water, and the lipid-packing density, without perturbing the hydrocarbon core of the bilayer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.