ArticleBiophysical journal2003
Mechanism of pH-triggered collapse of phosphatidylethanolamine liposomes stabilized by an ortho ester polyethyleneglycol lipid.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- PEGylation Enhances Colloidal Stability and Promotes Ligand-Mediated Targeting of LAF-Xenopeptide mRNA Complexes.Polymers · 2025Article
- The Chemical Reactivity of Membrane Lipids.Chemical reviews · 2024Review
- Key Design Features of Lipid Nanoparticles and Electrostatic Charge-Based Lipid Nanoparticle Targeting.Pharmaceutics · 2023Review
- Circulating microRNAs in Medicine.International journal of molecular sciences · 2022Review
- Molecular Switches-Tools for Imparting Control in Drug Delivery Systems.Frontiers in chemistry · 2022Review
- Lipid profile migration during the tilapia muscle steaming process revealed by a transactional analysis between MS data and lipidomics data.NPJ science of food · 2021Article
- Red blood cells: The metamorphosis of a neglected carrier into the natural mothership for artificial nanocarriers.Advanced drug delivery reviews · 2021Review
- Nanotechnology-Based Strategies to Overcome Current Barriers in Gene Delivery.International journal of molecular sciences · 2021Review
- Nanostructured Lipid-based Films for Substrate Mediated Applications in Biotechnology.Advanced functional materials · 2018Article
- Liposome-like Nanostructures for Drug Delivery.Journal of materials chemistry. B · 2013Article
- Lipid nature and their influence on opening of redox-active liposomes.Langmuir : the ACS journal of surfaces and colloids · 2013Article
- Acid-labile mPEG-vinyl ether-1,2-dioleylglycerol lipids with tunable pH sensitivity: synthesis and structural effects on hydrolysis rates, DOPE liposome release performance, and pharmacokinetics.Molecular pharmaceutics · 2012Article
- Acid-triggered release via dePEGylation of fusogenic liposomes mediated by heterobifunctional phenyl-substituted vinyl ethers with tunable pH-sensitivity.Bioconjugate chemistry · 2012Article
- Elastin-like peptide amphiphiles form nanofibers with tunable length.Biomacromolecules · 2012Article
- Novel pH-sensitive cationic lipids with linear ortho ester linkers for gene delivery.European journal of medicinal chemistry · 2012Article
- Biological stimuli and biomolecules in the assembly and manipulation of nanoscale polymeric particles.Chemical science · 2012Article
- Action and reaction: the biological response to siRNA and its delivery vehicles.Molecular therapy : the journal of the American Society of Gene Therapy · 2012Review
- Article
- Cytoplasmic delivery of liposomal contents mediated by an acid-labile cholesterol-vinyl ether-PEG conjugate.Bioconjugate chemistry · 2009Article
- Sheddable coatings for long-circulating nanoparticles.Pharmaceutical research · 2008Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The mechanism of pH-triggered destabilization of liposomes composed of a polyethyleneglycol-orthoester-distearoylglycerol lipid (POD) and phosphatidyl ethanolamine (PE) has been studied using an ANTS/DPX leakage and a lipid-mixing assay. We developed a kinetic model that relates POD hydrolysis to liposome collapse. This minimum-surface-shielding model describes the kinetics of the pH-triggered release of POD/PE liposomes. In the model, when acid-catalyzed hydrolysis lowers the mole percentage of POD on the liposome surface to a critical level, intervesicular lipid mixing is initiated, resulting in a burst of contents release. Two phases of content leakage are observed: a lag phase and a burst phase. During the lag phase, less than 20% of liposomal contents are released and the leakage begins to accelerate when approaching to the transition point. During the burst phase, the leakage rate is dependent on interbilayer contact. The burst phase occurs when the surface density of the PEG lipid is 2.3 +/- 0.6 mol%, regardless of the pH. Vesicles containing 4 mol% of a pH-insensitive PEG-lipid conjugate and 10% POD did not leak contents or collapse at any pH. These data are consistent with the stalk theory to describe the lamellar-to-inverted hexagonal phase transition and set a lower bound of approximately 16 PE lipids on the external monolayer as the contact site required for lipid mixing between two bilayers.
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Registered trials
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