ArticleBiophysical journal2003
Integrated luminal and cytosolic aspects of the calcium release control.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Signal mass and Ca²⁺ kinetics in local calcium events: a modeling study.Journal of molecular modeling · 2012Article
- Inositol trisphosphate receptor and ion channel models based on single-channel data.Chaos (Woodbury, N.Y.) · 2009Article
- An investigation of models of the IP3R channel in Xenopus oocyte.Chaos (Woodbury, N.Y.) · 2009Article
- A two-gate model for the ryanodine receptor with allosteric modulation by caffeine and quercetin.European biophysics journal : EBJ · 2008Article
- Hybrid stochastic and deterministic simulations of calcium blips.Biophysical journal · 2007Article
- A kinetic model of single and clustered IP3 receptors in the absence of Ca2+ feedback.Biophysical journal · 2007Article
- Gating mechanisms of the type-1 inositol trisphosphate receptor.Biophysical journal · 2005Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We propose here a unitary approach to the luminal and cytosolic control of calcium release. A minimal number of model elements that realistically describe different data sets are combined and adapted to correctly respond to various physiological constraints. We couple the kinetic properties of the inositol 1,4,5 trisphosphate receptor/calcium channel with the dynamics of Ca(2+) and K(+) in both the lumen and cytosol, and by using a detailed simulation approach, we propose that local (on a radial distance approximately 2 micro m) calcium oscillations in permeabilized cells are driven by the slow inactivation of channels organized in discrete clusters composed of between six and 15 channels. Moreover, the character of these oscillations is found to be extremely sensitive to K(+), so that the cytosolic and luminal calcium variations are in or out of phase if the store at equilibrium has tens or hundreds micro M Ca(2+), respectively, depending on the K(+) gradient across the reticulum membrane. Different patterns of calcium signals can be reproduced through variation of only a few parameters.
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