ArticleProceedings of the National Academy of Sciences of the United States of America2003
Lineage-restricted retention of a primitive immunoglobulin heavy chain isotype within the Dipnoi reveals an evolutionary paradox.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 76 citations in OpenAlex.
- Skin as outermost immune organ of vertebrates that elicits robust early immune responses after immunization with glycoprotein of spring viraemia of carp virus.PLoS pathogens · 2024Article
- The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms.Immunological reviews · 2024Review
- The immunoglobulins of cartilaginous fishes.Developmental and comparative immunology · 2021Review
- The Immune System and the Antiviral Responses in Chinese Giant Salamander,Frontiers in immunology · 2021Review
- A Comparison of the Innate and Adaptive Immune Systems in Cartilaginous Fish, Ray-Finned Fish, and Lobe-Finned Fish.Frontiers in immunology · 2019Review
- A cold-blooded view of adaptive immunity.Nature reviews. Immunology · 2018Review
- Immunoglobulin T from sea bass (Dicentrarchus labrax L.): molecular characterization, tissue localization and expression after nodavirus infection.BMC molecular biology · 2017Article
- Comparative transcriptomics of elasmobranchs and teleosts highlight important processes in adaptive immunity and regional endothermy.BMC genomics · 2017Article
- Fish Immunoglobulins.Biology · 2016Review
- The immunoglobulins of cold-blooded vertebrates.Biomolecules · 2014Review
- Genome complexity in the coelacanth is reflected in its adaptive immune system.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2014Article
- Intraclass diversification of immunoglobulin heavy chain genes in the African lungfish.Immunogenetics · 2014Article
- Noncoordinate expression of J-chain and Blimp-1 define nurse shark plasma cell populations during ontogeny.European journal of immunology · 2013Article
- Shark IgW C region diversification through RNA processing and isotype switching.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
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- Extensive diversification of IgH subclass-encoding genes and IgM subclass switching in crocodilians.Nature communications · 2013Article
- Expressional analysis of immunoglobulin D in cattle (Bos taurus), a large domesticated ungulate.PloS one · 2012Article
- Immunoglobulin heavy chains in medaka (Oryzias latipes).BMC evolutionary biology · 2011Article
- The origins of vertebrate adaptive immunity.Nature reviews. Immunology · 2010Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The lineage leading to lungfishes is one of the few major jawed vertebrate groups in which Ig heavy chain isotype structure has not been investigated at the genetic level. In this study, we have characterized three different Ig heavy chain isotypes of the African lungfish, Protopterus aethiopicus, including an IgM-type heavy chain and short and long forms of non-IgM heavy chains. Northern blot analysis as well as patterns of V(H) utilization suggest that the IgM and non-IgM isotypes are likely encoded in separate loci. The two non-IgM isotypes identified in Protopterus share structural features with the short and long forms of IgX/W/NARC (referred to hereafter as IgW), which were previously considered to be restricted to the cartilaginous fish. It seems that the IgW isotype has a far broader phylogenetic distribution than considered originally and raises questions with regard to the origin and evolutionary divergence of IgM and IgW. Moreover, its absence in other gnathostome lineages implies paradoxically that the IgW-type genes were lost from teleost and tetrapod lineages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.