ArticleThe EMBO journal2003
Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 177 citations in OpenAlex.
- Protein kinase C delta negatively modulates canonical Wnt pathway and cell proliferation in colon tumor cell lines.PloS one · 2013Trial
- The deubiquitinase USP17 regulates the expression and activity of the oncogenic driver β-catenin in colorectal cancer.Oncogene · 2026Article
- Article
- Article
- Mechanism of APC truncation involved in colorectal cancer tumorigenesis (Review).Oncology letters · 2025Review
- Review
- Adherens junction proteins on the move-From the membrane to the nucleus in intestinal diseases.Frontiers in cell and developmental biology · 2022Review
- Therapeutic Targeting of Exportin-1 in Childhood Cancer.Cancers · 2021Review
- Article
- Oncogenic Serine 45-Deleted β-Catenin Remains Susceptible to Wnt Stimulation and APC Regulation in Human Colonocytes.Cancers · 2020Article
- Wnt-driven LARGE2 mediates laminin-adhesive O-glycosylation in human colonic epithelial cells and colorectal cancer.Cell communication and signaling : CCS · 2020Article
- APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes.Scientific reports · 2020Article
- IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.The Journal of cell biology · 2020Article
- Human colon organoids reveal distinct physiologic and oncogenic Wnt responses.The Journal of experimental medicine · 2019Article
- Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models.Nature communications · 2019Article
- Msx1 loss suppresses formation of the ectopic crypts developed in the Apc-deficient small intestinal epithelium.Scientific reports · 2019Article
- Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting.Cancer metastasis reviews · 2018Review
- A novel mutation of adenomatous polyposis coli (APC) gene results in the formation of supernumerary teeth.Journal of cellular and molecular medicine · 2018Article
- c-Cbl mediates the degradation of tumorigenic nuclear β-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors.Oncotarget · 2016Article
- Regulation of functional KCNQ1OT1 lncRNA by β-catenin.Scientific reports · 2016Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adenomatous polyposis coli (APC) protein is inactivated in most colorectal tumours. APC loss is an early event in tumorigenesis, and causes an increase of nuclear beta-catenin and its transcriptional activity. This is thought to be the driving force for tumour progression. APC shuttles in and out of the nucleus, but the functional significance of this has been controversial. Here, we show that APC truncations are nuclear in colorectal cancer cells and adenocarcinomas, and this correlates with loss of centrally located nuclear export signals. These signals confer efficient nuclear export as measured directly by fluorescence loss in photobleaching (FLIP), and they are critical for the function of APC in reducing the transcriptional activity of beta-catenin in complementation assays of APC mutant colorectal cancer cells. Importantly, targeting a functional APC construct to the nucleus causes a striking nuclear accumulation of beta-catenin without changing its transcriptional activity. Our evidence indicates that the rate of nuclear export of APC, rather than its nuclear import or steady-state levels, determines the transcriptional activity of beta-catenin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.