ArticleClinical and experimental immunology2003
T cell Vbeta repertoires in childhood vasculitides.
Article in Clinical and experimental immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 46 citations in OpenAlex.
- Distribution of distinct subsets of circulating T follicular helper cells in Kawasaki disease.BMC pediatrics · 2019Article
- Variation in IL-21-secreting circulating follicular helper T cells in Kawasaki disease.BMC immunology · 2018Article
- T-cell receptor phenotype pattern in atopic children using commercial fluorescently labeled antibodies against 21 human class-specific v segments for the tcrβ chain (vβ) of peripheral blood: a cross sectional study.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2016Article
- Flow cytometric analysis of the CD4+ TCR Vβ repertoire in the peripheral blood of children with type 1 diabetes mellitus, systemic lupus erythematosus and age-matched healthy controls.BMC immunology · 2013Article
- Mycobacterium tuberculosis culture filtrate protein 10-specific effector/memory CD4⁺ and CD8⁺ T cells in tubercular pleural fluid, with biased usage of T cell receptor Vβ chains.Infection and immunity · 2011Article
- Kawasaki disease in ghana: case reports from Korle Bu teaching hospital.Ghana medical journal · 2011Article
- Medium-size-vessel vasculitis.Pediatric nephrology (Berlin, Germany) · 2010Review
- Vasculitis in children.Best practice & research. Clinical rheumatology · 2009Review
- T cell activation profiles in Kawasaki syndrome.Clinical and experimental immunology · 2008Article
- What's new in the aetiopathogenesis of vasculitis?Pediatric nephrology (Berlin, Germany) · 2007Review
- Immunological profile of peripheral blood lymphocytes and monocytes/macrophages in Kawasaki disease.Clinical and experimental immunology · 2005Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Superantigens (SAgs) are potent stimulators of T cells bearing specific Vbeta T cell receptors (TCR) and may play a role in the aetiopathogenesis of systemic vasculitis, although this remains contentious. To investigate the possible aetiological role of SAgs, this study examined peripheral blood T cell Vbeta repertoires in children with systemic vasculitis. FACS analysis of 17 different peripheral blood T cell Vbeta families was performed in 20 healthy control children, 27 disease control children with nonvasculitic inflammatory disease, 25 children with primary systemic vasculitis, six patients with Kawasaki disease (KD) and six patients with Henoch-Schönlein purpura (HSP). There was a significantly increased variance of CD4 Vbeta12 and Vbeta17, and CD8 Vbeta1 in the primary systemic vasculitis group compared to control and disease controls. Moreover, 80% of the primary systemic vasculitis children had one or more CD4 Vbeta expansions or deletions, compared with 30% of controls (P < 0.002), and 37% of the disease controls (P < 0.002). In the KD group, the mean percentage of CD4 Vbeta2 T cells was higher than in controls or disease controls. In the HSP group, there was no consistent skewing of the T cell Vbeta repertoire. We have observed changes in the T cell Vbeta repertoire in children with vasculitis over and above those observed in disease controls. While these data provide impetus for further research into this contentious field, they do not resolve unequivocally the question of the role of SAgs in childhood vasculitic syndromes.
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