ArticleClinical and experimental immunology2003
Live Leishmania promastigotes can directly activate primary human natural killer cells to produce interferon-gamma.
Article in Clinical and experimental immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 71 citations in OpenAlex.
- Revisiting the past in light of current knowledge on γδ T cells in leishmaniasis.Frontiers in immunology · 2026Review
- Leishmania Vaccines: the Current Situation with Its Promising Aspect for the Future.The Korean journal of parasitology · 2022Article
- Immune Responses in Cutaneous Leishmaniasis:Journal of arthropod-borne diseases · 2021Article
- Review on the Role of Host Immune Response in Protection and Immunopathogenesis during Cutaneous Leishmaniasis Infection.Journal of immunology research · 2020Review
- Cutaneous Leishmaniasis Due toEClinicalMedicine · 2018Review
- Monocyte-Derived Signals Activate Human Natural Killer Cells in Response toFrontiers in immunology · 2018Article
- Relationship of peripheral blood mononuclear cells miRNA expression and parasitic load in canine visceral leishmaniasis.PloS one · 2018Article
- Immunogenicity and protective efficacy of DNA vaccine against visceral leishmaniasis in BALB/c mice.Journal of biomedical research · 2016Article
- Article
- CD8 T cell exhaustion in human visceral leishmaniasis.The Journal of infectious diseases · 2014Article
- Article
- Protective immunity using MPL-A and autoclaved Leishmania donovani as adjuvants along with a cocktail vaccine in murine model of visceral leishmaniasis.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2013Article
- Naïve rat NK cells control the onset of T cell response.PloS one · 2012Article
- Vaccine Development Against Leishmania donovani.Frontiers in immunology · 2012Article
- Protective immunity and vaccination against cutaneous leishmaniasis.Frontiers in immunology · 2012Article
- Natural killer cells in experimental and human leishmaniasis.Frontiers in cellular and infection microbiology · 2012Review
- Protective and pathologic immune responses in human tegumentary leishmaniasis.Frontiers in immunology · 2012Article
- Human immunodeficiency virus and leishmaniasis.Journal of global infectious diseases · 2010Article
- T-bet, GATA-3, and Foxp3 expression and Th1/Th2 cytokine production in the clinical outcome of human infection with Leishmania (Viannia) species.The Journal of infectious diseases · 2010Article
- Immunological perspectives of leishmaniasis.Journal of global infectious diseases · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural killer (NK) cells have been implicated in the natural protection and healing of leishmaniasis by their ability to secrete the macrophage activating cytokine interferon (IFN)gamma. Previous studies have demonstrated that early production of interleukin (IL)-12 triggers IFN gamma secretion by NK cells. Here we report that live Leishmania promastigotes (the form that is injected by the vector) can directly induce human peripheral blood NK cells from healthy donors to IFN gamma secretion in the absence of IL-12 and professional antigen presenting cells. Killing of promastigotes abolishes this property. This novel mechanism of activation of the innate immune response may be relevant for establishment of infection and thus also the design of vaccines against leishmaniasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.