ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2003
Five-year results of trabeculectomy with mitomycin C.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Interventions for late trabeculectomy bleb leak.The Cochrane database of systematic reviews · 2012Pooled it
- The Primary Tube Versus Trabeculectomy Study: Methodology of a Multicenter Randomized Clinical Trial Comparing Tube Shunt Surgery and Trabeculectomy with Mitomycin C.Ophthalmology · 2018Trial
- Safety and efficacy of Intraurethral Mitomycin C Hydrogel for prevention of post-traumatic anterior urethral stricture recurrence after internal urethrotomy.Journal of injury & violence research · 2016Trial
- Comparison of outcomes of trabeculectomy with mitomycin C vs. ologen implant in primary glaucoma.Indian journal of ophthalmology · 2013Trial
- ISRCTN12125882 - Influence of topical anti-VEGF (Ranibizumab) on the outcome of filtration surgery for glaucoma - Study Protocol.BMC ophthalmology · 2011Trial
- A Systematic and Narrative Review of Safety and Complications in Minimally Invasive Glaucoma Surgery (MIGS) Between 2014-2024.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
- Five-year follow-up with the PreserFlo MicroShunt for open-angle glaucoma.Eye (London, England) · 2025Article
- Reassessing Trabeculectomy: A Long-Term Study with Stringent Success Criteria.Journal of clinical medicine · 2024Article
- Factors Associated with the Efficacy of XEN Gel Implant.Ophthalmology and therapy · 2024Article
- Contributing factors for intraocular pressure control in patients with mostly normal-tension glaucoma after initial Ex-PRESS drainage device implantation.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- The Role of STAT3 Signaling Pathway Activation in Subconjunctival Scar Formation after Glaucoma Filtration Surgery.International journal of molecular sciences · 2023Article
- Noncontact Conjunctiva: A Better Mitomycin C Application Site for Trabeculectomy.Ophthalmology and therapy · 2023Article
- Comparison of Ex-PRESS P-200 mini-shunt implantation and standard trabeculectomy for open-angle glaucoma: four-year follow-up.Archives of medical science : AMS · 2023Article
- Wound Healing Response After Bleb-Forming Glaucoma Surgery With a SIBS Microshunt in Rabbits.Translational vision science & technology · 2022Article
- Long-term results of the safety and effectiveness of a novel microshunt in Japanese patients with primary open-angle glaucoma.Japanese journal of ophthalmology · 2022Observational
- Long-term perimetric stabilization with a management algorithm of set target intraocular pressure in different severities of primary angle-closure glaucoma.Indian journal of ophthalmology · 2021Article
- Cross-linked hyaluronic acid viscoelastic scleral implant in trabeculectomy.Indian journal of ophthalmology · 2021Article
- Exploiting biomaterial approaches to manufacture an artificial trabecular meshwork: A progress report.Biomaterials and biosystems · 2021Review
- [Trabeculectomy with Ologen® implant and bevacizumab].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe long-term efficacy and safety of primary trabeculectomy with mitomycin C were retrospectively studied.
methodsSixty eyes of 60 patients with severe glaucoma, 25 female and 35 male, with a mean age of 72.5 years who underwent primary trabeculectomy with mitomycin C between 1993 and 1995 were included. Glaucoma subtypes consisted of 42 patients with primary open-angle glaucoma, 10 patients with normal-pressure glaucoma, 2 patients with chronic narrow-angle glaucoma, 5 patients with pigment dispersion syndrome and 1 patient with pseudoexfoliation syndrome. During surgery, mitomycin C 0.2 mg/ml was applied under the scleral flap for 3 min.
resultsMean intraocular pressure (IOP) decreased from 22.3+/-9.3 preoperatively to 12.6+/-3.5 mmHg postoperatively. With success defined as an IOP level of 15 mmHg or less, a success rate of 83.3% was obtained in the 1st year, dropping to 60% in the 6th year following trabeculectomy. Visual fields remained stable in 73.3% of cases during the follow-up period. LogMAR visual acuity increased from 0.2 to 0.4. Four eyes underwent cataract surgery prior to trabeculectomy. Thirteen eyes underwent cataract surgery during the follow-up period. Long-term complications were relatively mild and consisted of two cases of blebitis. Bleb reconstruction was performed in five eyes with overfiltration or bleb-related complaints.
conclusionsThe present findings indicate that the additional use of mitomycin C may be justified in trabeculectomies in patients with severe glaucoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.