ArticleInternational journal of impotence research2003
Increased contractility of diabetic rabbit corpora smooth muscle in response to endothelin is mediated via Rho-kinase beta.
Article in International journal of impotence research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 99 citations in OpenAlex.
- The effect of mirabegron, used for overactive bladder treatment, on female sexual function: a prospective controlled study.BMC urology · 2018Trial
- Constitutive LH receptor activity impairs NO-mediated penile smooth muscle relaxation.Reproduction (Cambridge, England) · 2021Article
- Elevated plasma aldosterone is an independent risk factor for erectile dysfunction in men.World journal of urology · 2016Article
- The role of phosphodiesterase-5 inhibitors in prostatic inflammation: a review.Journal of inflammation (London, England) · 2015Review
- The use of PDE-5 inhibitors in the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia.Current urology reports · 2013Review
- Erectile dysfunction - an update of current practice and future strategies.Journal of clinical urology · 2013Article
- Activated Rho kinase mediates diabetes-induced elevation of vascular arginase activation and contributes to impaired corpora cavernosa relaxation: possible involvement of p38 MAPK activation.The journal of sexual medicine · 2013Article
- Inhibition of Rho-kinase improves erectile function, increases nitric oxide signaling and decreases penile apoptosis in a rat model of cavernous nerve injury.The Journal of urology · 2013Article
- Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa.Journal of translational medicine · 2012Article
- Arginase II deletion increases corpora cavernosa relaxation in diabetic mice.The journal of sexual medicine · 2011Article
- RhoA/Rho-kinase and vascular diseases: what is the link?Cellular and molecular life sciences : CMLS · 2010Review
- The future is today: emerging drugs for the treatment of erectile dysfunction.Expert opinion on emerging drugs · 2010Review
- Article
- Urodynamic effects of once-daily tadalafil in men with LUTS secondary to clinical BPH.Current urology reports · 2010Article
- Up-regulation of the RhoA/Rho-kinase signaling pathway in corpus cavernosum from endothelial nitric-oxide synthase (NOS), but not neuronal NOS, null mice.The Journal of pharmacology and experimental therapeutics · 2010Article
- Deletion of SM-B, the high ATPase isoform of myosin, upregulates the PKC-mediated signal transduction pathway in murine urinary bladder smooth muscle.American journal of physiology. Renal physiology · 2009Article
- PDE5 inhibitors for LUTS.Prostate cancer and prostatic diseases · 2009Review
- Markers of erectile dysfunction.Indian journal of urology : IJU : journal of the Urological Society of India · 2008Article
- Molecular Yin and Yang of erectile function and dysfunction.Asian journal of andrology · 2008Review
- Gene transfer with a vector expressing Maxi-K from a smooth muscle-specific promoter restores erectile function in the aging rat.Gene therapy · 2008Article
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6 authors at 1 institution in 1 country.
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Abstract
Corpus cavernosum smooth muscle (CCSM) from rabbits made diabetic for 6 months as a result of alloxan injection exhibited increased sensitivity (3vs 9 nM EC(50)) and generated 20-50% greater force to endothelin-1 (ET-1) compared to CCSM from normal rabbits. In contrast, the force produced by the CCSM in response to KCl and phenylephrine was not significantly altered in diabetic CCSM. The increased ET-1 sensitivity is associated with a two to three-fold upregulation of ET receptor A at both mRNA and protein levels in diabetic CCSM. ET-1-induced CCSM contraction is largely dependent upon Rho-kinase (ROK), since it is almost completely blocked by Y-27632 (a highly selective ROK inhibitor). Furthermore, expression of ROKbeta isoform is selectively upregulated in CCSM from diabetic rabbits. Thus, an increased CCSM tone, modulated by sensitization of the endothelin-mediated contractile pathway via ROK, may be a key component of the molecular mechanism of diabetes-induced erectile dysfunction.
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