ArticleAntimicrobial agents and chemotherapy2003
Modulation of the activity of secretory phospholipase A2 by antimicrobial peptides.
Article in Antimicrobial agents and chemotherapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Phospholipase A2-A Significant Bio-Active Molecule in Honeybee (Molecules (Basel, Switzerland) · 2025Review
- An evaluation of the chemical content and microbiological contamination of Anatolian bee venom.PloS one · 2021Article
- Natural Occurrence in Venomous Arthropods of Antimicrobial Peptides Active against Protozoan Parasites.Toxins · 2019Review
- Preventive Effects of Bee Venom Derived Phospholipase A₂ on Oxaliplatin-Induced Neuropathic Pain in Mice.Toxins · 2016Article
- Review
- Phospholipase A2 inhibits cisplatin-induced acute kidney injury by modulating regulatory T cells by the CD206 mannose receptor.Kidney international · 2015Article
- Analgesic Effects of Bee Venom Derived Phospholipase A(2) in a Mouse Model of Oxaliplatin-Induced Neuropathic Pain.Toxins · 2015Article
- Viperatoxin-II: A novel viper venom protein as an effective bactericidal agent.FEBS open bio · 2015Article
- Article
- Short native antimicrobial peptides and engineered ultrashort lipopeptides: similarities and differences in cell specificities and modes of action.Cellular and molecular life sciences : CMLS · 2011Review
- Characterization of serum phospholipase a(2) activity in three diverse species of west african crocodiles.Biochemistry research international · 2011Article
- Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate.Antimicrobial agents and chemotherapy · 2010Article
- Amyloid-type fiber formation in control of enzyme action: interfacial activation of phospholipase A2.Biophysical journal · 2008Article
- The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease.Clinica chimica acta; international journal of clinical chemistry · 2007Review
- Cation-pi interactions stabilize the structure of the antimicrobial peptide indolicidin near membranes: molecular dynamics simulations.The journal of physical chemistry. B · 2007Article
- Antimicrobial peptides temporins B and L induce formation of tubular lipid protrusions from supported phospholipid bilayers.Biophysical journal · 2006Article
- Interaction of the gelsolin-derived antibacterial PBP 10 peptide with lipid bilayers and cell membranes.Antimicrobial agents and chemotherapy · 2006Article
- Antibacterial activities of rhodamine B-conjugated gelsolin-derived peptides compared to those of the antimicrobial peptides cathelicidin LL37, magainin II, and melittin.Antimicrobial agents and chemotherapy · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The antimicrobial peptides magainin 2, indolicidin, and temporins B and L were found to modulate the hydrolytic activity of secretory phospholipase A(2) (sPLA(2)) from bee venom and in human lacrimal fluid. More specifically, hydrolysis of phosphatidylcholine (PC) liposomes by bee venom sPLA(2) at 10 micro M Ca(2+) was attenuated by these peptides while augmented product formation was observed in the presence of 5 mM Ca(2+). The activity of sPLA(2) towards anionic liposomes was significantly enhanced by the antimicrobial peptides at low [Ca(2+)] and was further enhanced in the presence of 5 mM Ca(2+). Similarly, with 5 mM Ca(2+) the hydrolysis of anionic liposomes was enhanced significantly by human lacrimal fluid sPLA(2), while that of PC liposomes was attenuated. These results indicate that concerted action of antimicrobial peptides and sPLA(2) could improve the efficiency of the innate response to infections. Interestingly, inclusion of a cationic gemini surfactant in the vesicles showed an essentially similar pattern on sPLA(2) activity, suggesting that the modulation of the enzyme activity by the antimicrobial peptides may involve also charge properties of the substrate surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.