Evidence map›Paper›PMID 12603998›Full record

ArticleEmerging infectious diseases2003

B-virus (Cercopithecine herpesvirus 1) infection in humans and macaques: potential for zoonotic disease.

Jennifer L Huff, Peter A Barry

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 231 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Herpes B virus and the neglected risk of zoonotic spillover.One health (Amsterdam, Netherlands) · 2026
    Review
  6. Review
  7. Article
  8. Review
  9. A narrative review of monkey B virus (Clinical and experimental vaccine research · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Host-Parasite Coevolution in Primates.Life (Basel, Switzerland) · 2023
    Review
  20. Review

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jennifer L HuffDepartment of Medical Microbiology and Immunology, University of California, Davis, California 95616, USA. jlmshuff@ucdavis.edu
Peter A Barry
University of California, Davis · US

Funding

LABORATORY MEDICINE TRAINING PROGRAMT32RR007038 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI BARTHOLD, STEPHEN WILLIAM · 1988 to 2011
$4.0M
NCRR NIH HHS RR07038NCRR NIH HHS T32 RR007038
6 · The paper itself

Abstract

Nonhuman primates are widely used in biomedical research because of their genetic, anatomic, and physiologic similarities to humans. In this setting, human contact directly with macaques or with their tissues and fluids sometimes occurs. Cercopithecine herpesvirus 1 (B virus), an alphaherpesvirus endemic in Asian macaques, is closely related to herpes simplex virus (HSV). Most macaques carry B virus without overt signs of disease. However, zoonotic infection with B virus in humans usually results in fatal encephalomyelitis or severe neurologic impairment. Although the incidence of human infection with B virus is low, a death rate of >70% before the availability of antiviral therapy makes this virus a serious zoonotic threat. Knowledge of the clinical signs and risk factors for human B-virus disease allows early initiation of antiviral therapy and prevents severe disease or death.

Indexed as

Herpesvirus 1, CercopithecineAnimalsCommunicable Diseases, EmergingHerpesviridae InfectionsHumansMacacaMonkey DiseasesViral VaccinesZoonosesViral Vaccines

Identifiers

PMID12603998
PMCPMC2901951
OpenAlexW2107993974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.