ArticleJournal of neurochemistry2003
Interleukin-1beta stimulates macrophage inflammatory protein-1alpha and -1beta expression in human neuronal cells (NT2-N).
Article in Journal of neurochemistry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- A quantitative transcriptome reference map of the normal human brain.Neurogenetics · 2014Pooled it
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- Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain.Experimental biology and medicine (Maywood, N.J.) · 2023Article
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- Proteomic Analysis of Cyclic Ketamine Compounds Ability to Induce Neural Differentiation in Human Adult Mesenchymal Stem Cells.International journal of molecular sciences · 2019Article
- Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
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- Potential Adverse Effects of Prolonged Sevoflurane Exposure on Developing Monkey Brain: From Abnormal Lipid Metabolism to Neuronal Damage.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- p38α (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes.Scientific reports · 2014Article
- IL-29/IL-28A suppress HSV-1 infection of human NT2-N neurons.Journal of neurovirology · 2011Article
- Caspase-1 modulates incisional sensitization and inflammation.Anesthesiology · 2010Article
- Activation of toll-like receptor-3 induces interferon-lambda expression in human neuronal cells.Neuroscience · 2009Article
- Expression and regulation of antiviral protein APOBEC3G in human neuronal cells.Journal of neuroimmunology · 2009Article
- Ethanol regulates angiogenic cytokines during neural development: evidence from an in vitro model of mitogen-withdrawal-induced cerebral cortical neuroepithelial differentiation.Alcoholism, clinical and experimental research · 2007Article
- The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA.Journal of molecular neuroscience : MN · 2006Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Chemokines are important mediators in immune responses and inflammatory processes of neuroimmunologic and infectious diseases. Although chemokines are expressed predominantly by cells of the immune system, neurons also express chemokines and chemokine receptors. We report herein that human neuronal cells (NT2-N) produce macrophage inflammatory protein-1alpha and -1beta (MIP-1alpha and MIP-1beta), which could be enhanced by interleukin (IL)-1beta at both mRNA and protein levels. The addition of supernatants from human peripheral blood monocyte-derived macrophage (MDM) cultures induced MIP-1beta mRNA expression in NT2-N cells. Anti-IL-1beta antibody removed most, but not all, of the MDM culture supernatant-induced MIP-1beta mRNA expression in NT2-N cells, suggesting that IL-1beta in the MDM culture supernatants is a major factor in the induction of MIP-1beta expression. Investigation of the mechanism(s) responsible for IL-1beta-induced MIP-1alpha and -1beta expression demonstrated that IL-1beta activated nuclear factor kappa B (NF-kappaB) promoter-directed luciferase activity in NT2-N cells. Caffeic acid phenethyl ester, a potent and specific inhibitor of activation of NF-kappaB, not only blocked IL-1beta-induced activation of the NF-kappaB promoter but also decreased IL-1beta-induced MIP-1alpha and -1beta expression in NT2-N cells. These data suggest that NF-kappaB is at least partially involved in the IL-1beta-mediated action on MIP-1alpha and -1beta in NT2-N cells. IL-1beta-mediated up-regulation of beta-chemokine expression may have important implications in the immunopathogenesis of inflammatory diseases in the CNS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.