ArticleMolecular microbiology2003
Iron and contact with host cells induce expression of adhesins on surface of Trichomonas vaginalis.
Article in Molecular microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 103 citations in OpenAlex.
- Evaluation of the effect of metronidazole administration on the pathophysiology of trichomonas vaginalis infection among pregnant women in Ghana.BMC infectious diseases · 2026Article
- Interactions between bacterial vaginosis-associated microbiota and Trichomonas vaginalis modulate parasite-induced pathogenicity and host immune responses.Parasites & vectors · 2025Article
- An Atypical F-Actin Capping Protein Modulates Cytoskeleton Behaviors Crucial for Trichomonas vaginalis Colonization.Microbiology spectrum · 2023Article
- Hemoglobin uptake and utilization by human protozoan parasites: a review.Frontiers in cellular and infection microbiology · 2023Review
- The Iron Response ofFrontiers in cellular and infection microbiology · 2022Review
- Development of a convenient detection method for Trichomonas vaginalis based on loop-mediated isothermal amplification targeting adhesion protein 65.BMC infectious diseases · 2020Article
- Endomembrane Protein Trafficking Regulated by a TvCyP2 Cyclophilin in the Protozoan Parasite, Trichomonas vaginalis.Scientific reports · 2020Article
- Ginger (Zingiber officinale) induces apoptosis in Trichomonas vaginalis in vitro.International journal of reproductive biomedicine · 2016Article
- The Glycolytic Enzyme Triosephosphate Isomerase of Trichomonas vaginalis Is a Surface-Associated Protein Induced by Glucose That Functions as a Laminin- and Fibronectin-Binding Protein.Infection and immunity · 2016Article
- Trichomoniasis - are we giving the deserved attention to the most common non-viral sexually transmitted disease worldwide?Microbial cell (Graz, Austria) · 2016Review
- Modulatory effect of iron chelators on adenosine deaminase activity and gene expression in Trichomonas vaginalis.Memorias do Instituto Oswaldo Cruz · 2015Article
- Iron from haemoglobin and haemin modulates nucleotide hydrolysis in Trichomonas vaginalis.Memorias do Instituto Oswaldo Cruz · 2015Article
- Article
- Regulation of nuclear translocation of the Myb1 transcription factor by TvCyclophilin 1 in the protozoan parasite Trichomonas vaginalis.The Journal of biological chemistry · 2014Article
- Biological roles of cysteine proteinases in the pathogenesis of Trichomonas vaginalis.Parasite (Paris, France) · 2014Review
- Epitopes of the highly immunogenic Trichomonas vaginalis α-actinin are serodiagnostic targets for both women and men.Journal of clinical microbiology · 2013Article
- TvMP50 is an immunogenic metalloproteinase during male trichomoniasis.Molecular & cellular proteomics : MCP · 2013Article
- Identification, characterization, and synthesis of peptide epitopes and a recombinant six-epitope protein for Trichomonas vaginalis serodiagnosis.ImmunoTargets and therapy · 2013Article
- Iron-inducible nuclear translocation of a Myb3 transcription factor in the protozoan parasite Trichomonas vaginalis.Eukaryotic cell · 2012Article
- Comparative transcriptomic and proteomic analyses of Trichomonas vaginalis following adherence to fibronectin.Infection and immunity · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The proteins AP65, AP51, AP33 and AP23 synthesized by Trichomonas vaginalis organisms in high iron play a role in adherence. Multigene families encode enzymes of the hydrogenosome organelles, which have identity to adhesins. This fact raises questions regarding the compartmentalization of the proteins outside the organelle and about the interactions of adhesins with host cells. Data here demonstrate the presence of the proteins outside the organelle under high-iron conditions. Fluorescence and immuno-cytochemical experiments show that high-iron-grown organisms coexpressed adhesins on the surface and intracellularly in contrast with low-iron parasites. Furthermore, the AP65 epitopes seen by rabbit anti-AP65 serum that blocks adherence and detects surface proteins were identified, and a mAb reacting to those epitopes recognized the trichomonal surface. Two-dimensional electrophoresis and immunoblot of adhesins from surface-labelled parasites provided evidence that all members of the multigene family were co-ordinately expressed and placed on the trichomonal surface. Similar two-dimensional analysis of proteins from purified hydrogenosomes obtained from iodinated trichomonads confirmed the specific surface labelling of proteins. Contact of trichomonads with vaginal epithelial cells increased the amount of surface-expressed adhesins. Moreover, we found a direct relationship between the levels of adherence and amount of adhesins bound to immortalized vaginal and ureter epithelial cells, further reinforcing specific associations. Finally, trichomonads of MR100, a drug-resistant isolate absent in hydrogenosome proteins and adhesins, were non-adherent. Overall, the results confirm an important role for iron and contact in the surface expression of adhesins of T. vaginalis organisms.
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Registered trials
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