ArticleImmunology2003
Histopathological outcome of Leishmania major-infected BALB/c mice is improved by oral treatment with N-acetyl-l-cysteine.
Article in Immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- Transcription Factors Interplay Orchestrates the Immune-Metabolic Response ofFrontiers in cellular and infection microbiology · 2021Review
- Antioxidant defense in the eyes of immunocompetent and immunosuppressed mice infected with Acanthamoeba spp.Parasites & vectors · 2020Article
- N-acetyl-L-cysteine reduces Leishmania amazonensis-induced inflammation in BALB/c mice.BMC veterinary research · 2020Article
- RANK Ligand Helps Immunity toFrontiers in immunology · 2020Article
- Novel Nanosized Chitosan-Betulinic Acid Against Resistant Leishmania Major and First Clinical Observation of such parasite in Kidney.Scientific reports · 2018Article
- Reduction toxicity of Amphotericin B through loading into a novel nanoformulation of anionic linear globular dendrimer for improve treatment of leishmania major.Journal of materials science. Materials in medicine · 2018Article
- N-acetyl-cysteine inhibits liver oxidative stress markers in BALB/c mice infected with Leishmania amazonensis.Memorias do Instituto Oswaldo Cruz · 2017Article
- Immunoregulation in human American leishmaniasis: balancing pathology and protection.Parasite immunology · 2014Review
- Are reactive oxygen species always detrimental to pathogens?Antioxidants & redox signaling · 2014Review
- A novel function for kojic acid, a secondary metabolite from Aspergillus fungi, as antileishmanial agent.PloS one · 2014Article
- Article
- Role of ROS in ischemia-induced lung angiogenesis.American journal of physiology. Lung cellular and molecular physiology · 2010Article
- N-acetyl-L: -cysteine reduces the parasitism of BALB/c mice infected with Leishmania amazonensis.Parasitology research · 2008Article
- N-acetylcysteine -- passe-partout or much ado about nothing?British journal of clinical pharmacology · 2006Review
- Resistance of Leishmania donovani to sodium stibogluconate is related to the expression of host and parasite gamma-glutamylcysteine synthetase.Antimicrobial agents and chemotherapy · 2006Article
- Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation.Clinical and experimental immunology · 2004Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leishmania major infected BALB/c mice were treated with N-acetyl-l-cysteine (NAC), a glutathione precursor, to evaluate the role of in vivo glutathione on lesion pathology and cytokine profiles following infection. Mice were maintained on NAC-containing water 2 days before infection for a total of 14 weeks. The BALB/c response to L. major infection was improved by oral administration of NAC, at the level of histopathological outcome, lesion progression and cytokine profile. A significantly improved histopathological outcome of the footpad lesion, characterized by a mixed inflammatory infiltrate organized in a focal pattern with little tissue destruction and a reduced parasite load, was observed in NAC-treated BALB/c mice. Histopathological modulation was accompanied by a modified cytokine pattern from popliteal lymph node cells, demonstrated by a sustained higher frequency of interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha)-producing cells. This work points to an important role for glutathione in the modulation of effector responses in BALB/c mice.
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