ArticlePlant molecular biology2003
A maize histone deacetylase and retinoblastoma-related protein physically interact and cooperate in repressing gene transcription.
Article in Plant molecular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 77 citations in OpenAlex.
- Regulation of cell cycle in plant gametes: when is the right time to divide?Development (Cambridge, England) · 2025Review
- The Italian Research on the Molecular Characterization of Maize Kernel Development.International journal of molecular sciences · 2022Review
- Pickle Recruits Retinoblastoma Related 1 to Control Lateral Root Formation inInternational journal of molecular sciences · 2021Article
- Roles of plant retinoblastoma protein: cell cycle and beyond.The EMBO journal · 2020Review
- Beyond What Your Retina Can See: Similarities of Retinoblastoma Function between Plants and Animals, from Developmental Processes to Epigenetic Regulation.International journal of molecular sciences · 2020Review
- Cell type specific transcriptional reprogramming of maize leaves during Ustilago maydis induced tumor formation.Scientific reports · 2019Article
- Control of Maize Vegetative and Reproductive Development, Fertility, and rRNAs Silencing byGenetics · 2018Article
- Characterization and Expression Analysis of Common BeanInternational journal of genomics · 2017Article
- Arabidopsis DNA polymerase ϵ recruits components of Polycomb repressor complex to mediate epigenetic gene silencing.Nucleic acids research · 2016Article
- Genome-Wide Mapping of Targets of Maize Histone Deacetylase HDA101 Reveals Its Function and Regulatory Mechanism during Seed Development.The Plant cell · 2016Article
- The histone deacetylase inhibitor trichostatin a promotes totipotency in the male gametophyte.The Plant cell · 2014Article
- In silico analysis of protein Lys-N(𝜀)-acetylation in plants.Frontiers in plant science · 2014Review
- Looking at plant cell cycle from the chromatin window.Frontiers in plant science · 2014Review
- Control of cell proliferation, endoreduplication, cell size, and cell death by the retinoblastoma-related pathway in maize endosperm.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Histone deacetylases and their functions in plants.Plant cell reports · 2013Review
- The WD40-repeat proteins NFC101 and NFC102 regulate different aspects of maize development through chromatin modification.The Plant cell · 2013Article
- Role of HD2 genes in seed germination and early seedling growth in Arabidopsis.Plant cell reports · 2011Article
- FVE, an Arabidopsis homologue of the retinoblastoma-associated protein that regulates flowering time and cold response, binds to chromatin as a large multiprotein complex.Molecules and cells · 2011Article
- Retinoblastoma protein is essential for early meiotic events in Arabidopsis.The EMBO journal · 2011Article
- Regulation of the Chlamydomonas cell cycle by a stable, chromatin-associated retinoblastoma tumor suppressor complex.The Plant cell · 2010Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammalian cells the product of the human retinoblastoma tumour suppressor gene (pRb) can recruit Rpd3-like histone deacetylases to repress transcription. In this study, we investigated whether this mechanism might also be relevant in plants and found both conserved and distinct features. The expression profiles of the Zea mays Rpd3-type histone deacetylase (ZmRpd3I) and the retinoblastoma-related (ZmRBR1) homologues were analysed during endosperm development. GST pull-down and immunoprecipitation experiments showed a physical interaction between ZmRBRI and ZmRpd3I. Because ZmRpd3I lacks a LXCXE motif, conserved in several pRb-interacting proteins, we have mapped the amino acid domains involved in the ZmRBR1/ZmRpd3I interaction. Furthermore, we observed that ZmRbAp1, a maize member of the MSI/RbAp family, facilitated this protein interaction. Co-transformations of tobacco protoplasts with plasmids expressing ZmRBRI and ZmRpd3I showed that the two proteins cooperate in repressing gene transcription. Our findings represent the first indication that in plants a regulator of important biological processes, ZmRBRI, can recruit a histone deacetylase, ZmRpd3I, to control gene transcription.
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