Evidence map›Paper›PMID 12601502›Full record

Trial reportPsychopharmacology2003

Efficacy of acute administration of nicotine gum in relief of cue-provoked cigarette craving.

Saul Shiffman, William G Shadel, Raymond Niaura, Moise A Khayrallah, Douglas E Jorenby, Charles F Ryan, Clifford L Ferguson

Abstract readClinical TrialMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Psychopharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Using Nicotine Gum to Assist Nondaily Smokers in Quitting: A Randomized Clinical Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020
    Trial
  5. Trial
  6. Pleasant olfactory cues can reduce cigarette craving.Journal of abnormal psychology · 2019
    Trial
  7. Trial
  8. Trial
  9. Does Extended Pre Quit Bupropion Aid in Extinguishing Smoking Behavior?Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015
    Trial
  10. Pharmacokinetic-pharmacodynamic modeling of the effect of varenicline on nicotine craving in adult smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015
    Trial
  11. Trial
  12. Trial
  13. Effects of nicotine deprivation and replacement on BOLD-fMRI response to smoking cues as a function of DRD4 VNTR genotype.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2014
    Trial
  14. Decline in cue-provoked craving during cue exposure therapy for smoking cessation.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2014
    Trial
  15. Trial
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  18. Lapse-induced surges in craving influence relapse in adult smokers: an experimental investigation.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2011
    Trial
  19. The effects of nicotine replacement on cognitive brain activity during smoking withdrawal studied with simultaneous fMRI/EEG.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011
    Trial
  20. Trial

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Saul ShiffmanPinney Associates and the University of Pittsburgh, 201 North Craig Street, Suite 320, Pittsburgh, PA 15213, USA. shiffman@pinneyassociates.com
William G Shadel
Raymond Niaura
Moise A Khayrallah
Douglas E Jorenby
Charles F Ryan
Clifford L Ferguson

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleAcute cravings, often provoked by exposure to smoking cues, appear to be important triggers for smoking relapse. Relief of acute craving may therefore be an important step in preventing relapse.

objectivesThis study was undertaken to assess the effectiveness of nicotine gum in relieving acute craving.

methodsA multi-center, randomized, placebo-controlled study was conducted with smokers ( n=296) who quit by using either active or inactive gum for 3 days. On their third day of abstinence, smokers participated in a laboratory session in which they were exposed to a provocative smoking cue, chewed active or inactive gum, and then rated their craving at 5-min intervals for 35 min.

resultsCraving initially decreased in both groups. After 15 min, however, the smokers using active nicotine gum experienced significantly greater craving reductions.

conclusionsThese results suggest that nicotine gum can effectively reduce acute craving following exposure to smoking cues.

Indexed as

Chewing GumCuesSmoking PreventionAdultAnalysis of VarianceFemaleHumansMaleNicotineSmokingSmoking CessationTreatment OutcomeChewing GumNicotine

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.