ArticleHuman genetics2003
Genetic demography of Antioquia (Colombia) and the Central Valley of Costa Rica.
Article in Human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- Building a hereditary cancer program in Colombia: analysis of germline pathogenic and likely pathogenic variants spectrum in a high-risk cohort.European journal of human genetics : EJHG · 2025Article
- Genetic Ancestry and Lung Cancer in Latin American Patients: A Crucial Step for Understanding a Diverse Population.Clinical lung cancer · 2025Review
- The role of multi-organ cancer predisposition genes in the risk of inherited and histologically diverse gastric cancer.EBioMedicine · 2025Article
- Variants in candidate genes and their interactions with smoking on the risk of acute coronary syndromeBiomedica : revista del Instituto Nacional de Salud · 2025Article
- Native American ancestry and breast cancer risk in Colombian and Mexican women: ruling out potential confounding through ancestry-informative markers.Breast cancer research : BCR · 2023Article
- A review of ancestrality and admixture in Latin America and the caribbean focusing on native American and African descendant populations.Frontiers in genetics · 2023Review
- Dental size variation in admixed Latin Americans: Effects of age, sex and genomic ancestry.PloS one · 2023Article
- Apolipoprotein E polymorphisms in adults over 60 years of age with mild cognitive impairment and Alzheimer’s disease in different Venezuelan populationsBiomedica : revista del Instituto Nacional de Salud · 2022Article
- Neuronal Ceroid Lipofuscinosis Type 6 (CLN6) clinical findings and molecular diagnosis: Costa Rica's experience.Orphanet journal of rare diseases · 2022Article
- A Cancer Health Needs Assessment Reveals Important Differences Between US-Born and Foreign-Born Latinos in California.Frontiers in oncology · 2022Article
- Article
- Genome-wide mapping of brain phenotypes in extended pedigrees with strong genetic loading for bipolar disorder.Molecular psychiatry · 2021Article
- Haplotype analysis of the internationally distributed BRCA1 c.3331_3334delCAAG founder mutation reveals a common ancestral origin in Iberia.Breast cancer research : BCR · 2020Article
- Development of a small panel of SNPs to infer ancestry in Chileans that distinguishes Aymara and Mapuche components.Biological research · 2020Article
- Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates.Translational psychiatry · 2020Article
- The Genetic Population Structure of Robinson Crusoe Island, Chile.Frontiers in genetics · 2020Article
- BRAF and TERT mutations in papillary thyroid cancer patients of Latino ancestry.Endocrine connections · 2019Article
- Genetic admixture patterns in Argentinian Patagonia.PloS one · 2019Article
- Understanding the Hidden Complexity of Latin American Population Isolates.American journal of human genetics · 2018Article
- A Comparative Analysis of Genetic Ancestry and Admixture in the Colombian Populations of Chocó and Medellín.G3 (Bethesda, Md.) · 2017Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
Funding
Abstract
We report a comparative genetic characterization of two population isolates with parallel demographic histories: the Central Valley of Costa Rica (CVCR) and Antioquia (in northwest Colombia). The analysis of mtDNA, Y-chromosome and autosomal polymorphisms shows that Antioquia and the CVCR are genetically very similar, indicating that closely related parental populations founded these two isolates. In both populations, the male ancestry is predominantly European, whereas the female ancestry is mostly Amerind. In agreement with their isolation, the Amerindian mtDNA diversity of Antioquia and the CVCR is typical of ethnically-defined native populations and is markedly lower than in other Latin American populations. A comparison of linkage disequilibrium (LD) at 18 marker pairs in Antioquia and the CVCR shows that markers in LD in both populations are located at short genetic distances (<approximately 1 cM), whereas markers separated by greater distances are in LD only in the CVCR. This difference probably reflects stochastic variation of LD at the limited number of genome regions compared. The genetic similarity of the populations from Antioquia and the CVCR together with differences in LD between them should be exploitable for the identification and fine mapping of shared disease-related gene variants.
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