ArticleProceedings of the National Academy of Sciences of the United States of America2003
Maternal induction of ventral fate by zebrafish radar.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 70 citations in OpenAlex.
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- A multistep computational approach reveals a neuro-mesenchymal cell population in the embryonic hematopoietic stem cell niche.Development (Cambridge, England) · 2024Article
- Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways.Nature communications · 2021Article
- Transgenic fluorescent zebrafish lines that have revolutionized biomedical research.Laboratory animal research · 2021Review
- Segregation of brain and organizer precursors is differentially regulated by Nodal signaling at blastula stage.Biology open · 2021Article
- BMP Signaling: Lighting up the Way for Embryonic Dorsoventral Patterning.Frontiers in cell and developmental biology · 2021Review
- The lateral plate mesoderm.Development (Cambridge, England) · 2020Review
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- Therapeutic potential of growth differentiation factors in the treatment of degenerative disc diseases.JOR spine · 2019Review
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- TGF-β Family Signaling in Early Vertebrate Development.Cold Spring Harbor perspectives in biology · 2018Review
- Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
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- Axis Patterning by BMPs: Cnidarian Network Reveals Evolutionary Constraints.Cell reports · 2015Article
- Long-chain Acyl-CoA synthetase 4A regulates Smad activity and dorsoventral patterning in the zebrafish embryo.Developmental cell · 2013Article
- The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands.Developmental biology · 2013Article
- Morphogenesis and cell fate determination within the adaxial cell equivalence group of the zebrafish myotome.PLoS genetics · 2012Article
- Tumor suppressor Lzap regulates cell cycle progression, doming, and zebrafish epiboly.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Identification of a distant cis-regulatory element controlling pharyngeal arch-specific expression of zebrafish gdf6a/radar.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Maternal-zygotic epistasis and the evolution of genetic diseases.Journal of biomedicine & biotechnology · 2010Article
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4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vertebrate embryos, maternal determinants are thought to preestablish the dorsoventral axis by locally activating zygotic ventral- and dorsal-specifying genes, e.g., genes encoding bone morphogenetic proteins (BMPs) and BMP inhibitors, respectively. Whereas the canonical Wntbeta-catenin pathway fulfills this role dorsally, the existence of a reciprocal maternal ventralizing signal remains hypothetical. Maternal noncanonical WntCa(2+) signaling may promote ventral fates by suppressing Wntbeta-catenin dorsalizing signals; however, whether any maternal determinant is directly required for the activation of zygotic ventral-specifying genes is unknown. Here, we show that such a function is achieved, in part, in the zebrafish embryo by the maternally encoded transforming growth factor beta (TGF-beta) signaling molecule, Radar. Loss-of-function experiments, together with epistasis analyses, identify maternal Radar as an upstream activator of bmps expression. Maternal induction of bmps by Radar is essential for zebrafish development as its removal results in larval-lethal dorsalized phenotypes. Double-morphant analyses further suggest that Radar functions through the TGF-beta receptor Alk8 to initiate the expression of bmp genes. Our results support the existence of a previously uncharacterized maternal ventralizing pathway. They might further indicate that maternal TGF-betaRdr and WntCa(2+) pathways complementarily specify ventral cell fates, with the former triggering bmps expression and the latter indirectly repressing genes encoding BMP antagonists.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.