ArticleAmerican journal of respiratory cell and molecular biology2003
Cytokine-chemokine networks in experimental mycobacterial and schistosomal pulmonary granuloma formation.
Article in American journal of respiratory cell and molecular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 81 citations in OpenAlex.
- COVID-19 and Parasitic Co-Infection: A Hypothetical Link to Pulmonary Vascular Disease.Infectious disease reports · 2025Review
- Analysis of alpha-1-antitrypsin (AAT)-regulated, glucocorticoid receptor-dependent genes in macrophages reveals a novel host defense function of AAT.Physiological reports · 2024Article
- Therapeutic potential of natural products in schistosomiasis-associated liver fibrosis.Frontiers in pharmacology · 2024Review
- Prevalence and Clinical Relevance ofOpen journal of epidemiology · 2023Article
- Deriving a Boolean dynamics to reveal macrophage activation with in vitro temporal cytokine expression profiles.BMC bioinformatics · 2019Article
- Schistosome infection and its effect on pulmonary circulation.Global cardiology science & practice · 2019Review
- Coexistent Helminth Infection-Mediated Modulation of Chemokine Responses in Latent Tuberculosis.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Pulmonary immunity and extracellular matrix interactions.Matrix biology : journal of the International Society for Matrix Biology · 2018Review
- An IFNγ/CXCL2 regulatory pathway determines lesion localization during EAE.Journal of neuroinflammation · 2018Article
- Role of chemokine C-C motif ligand-1 in acute and chronic pulmonary inflammations.SpringerPlus · 2016Article
- Genetic polymorphisms of CCL1 rs2072069 G/A and TLR2 rs3804099 T/C in pulmonary or meningeal tuberculosis patients.International journal of clinical and experimental pathology · 2015Article
- Schistosomiasis-associated pulmonary hypertension.Pulmonary circulation · 2014Review
- Mycobacterial trehalose dimycolate reprograms macrophage global gene expression and activates matrix metalloproteinases.Infection and immunity · 2013Article
- Mycobacterium marinum: a potential immunotherapy for Mycobacterium tuberculosis infection.Drug design, development and therapy · 2013Article
- The schistosoma granuloma: friend or foe?Frontiers in immunology · 2013Article
- Chemokines in innate and adaptive granuloma formation.Frontiers in immunology · 2013Article
- A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians.BMC medical genetics · 2012Article
- Therapeutic DNA vaccine reduces schistosoma mansoni-induced tissue damage through cytokine balance and decreased migration of myofibroblasts.The American journal of pathology · 2011Article
- Development of a sarcoidosis murine lung granuloma model using Mycobacterium superoxide dismutase A peptide.American journal of respiratory cell and molecular biology · 2011Article
- Global gene expression profile progression in Gaucher disease mouse models.BMC genomics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Type-1 and type-2 lung granulomas, respectively, elicited by bead immobilized Mycobacteria bovis and Schistosoma mansoni egg antigens (Ags) display different patterns of chemokine expression. This study tested the hypothesis that chemokine expression patterns were related to upstream cytokine signaling. Using quantitative transcript analysis, we defined expression profiles for 16 chemokines and then examined the in vivo effects of neutralizing antibodies against interferon-gamma (IFN-gamma), interleukin (IL)-4, IL-10, IL-12, and IL-13. Transcripts for CXCL2, -5, -9, -10, and -11 and the CCL chemokine, CCL3, and lymphotactin (XCL1), were largely enhanced by Th1-related cytokines, IFN-gamma or IL-12. Transcripts for CCL11, CCL22, CCL17, and CCL1 were enhanced largely by Th2-related cytokines, IL-4, IL-10, or IL-13. Transcripts for CCL4, CCL2, CCL8, CCL7, and CCL12 were potentially induced by either Th1- or Th2-related cytokines, although some of these showed biased expression. IFN-gamma and IL-4 enhanced the greatest complement of transcripts, and their neutralization had the greatest anti-inflammatory effect on type-1 and type-2 granulomas, respectively. Th1/Th2 cross-regulation was evident because endogenous Th2 cytokines inhibited type-1, whereas Th1 cytokines inhibited type-2 biased chemokines. These findings reveal a complex cytokine-chemokine regulatory network that dictates profiles of local chemokine expression during T cell-mediated granuloma formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.