ArticleBMC cell biology2003
Control of T lymphocyte morphology by the GTPase Rho.
Article in BMC cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Characterization of a Cdc42 protein inhibitor and its use as a molecular probe.The Journal of biological chemistry · 2013Article
- Article
- Multiple roles for RhoA during T cell transendothelial migration.Small GTPases · 2010Article
- Antigen-independent adhesion and cell spreading by inducible costimulator engagement inhibits T cell migration in a PI-3K-dependent manner.Journal of leukocyte biology · 2009Article
- Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- RhoGTPases and p53 are involved in the morphological appearance and interferon-alpha response of hairy cells.The American journal of pathology · 2006Article
- Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- Expression of RhoA by inflammatory macrophages and T cells in rat experimental autoimmune neuritis.Journal of cellular and molecular medicineArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundRho family GTPase regulation of the actin cytoskeleton governs a variety of cell responses. In this report, we have analyzed the role of the GTPase Rho in maintenance of the T lymphocyte actin cytoskeleton.
resultsInactivation of the GTPase Rho in the human T lymphocytic cell line HPB-ALL does not inhibit constitutively high adhesion to the integrin beta1 substrate fibronectin. It did however result in the aberrant extension of finger-like dendritic processes on the substrates VCAM-1, Fn, and mAb specific to beta1 integrins. Time-lapse video microscopy demonstrated that C3 induced extensions were primarily the result of an altered pseudopod elongation rather than retraction. Once the stellate pseudopodia extended, none retracted, and cells became completely immobile. Filipodial structures were absent and the dendritic-like processes in C3 treated cells were rich in filamentous actin. Immunolocalization of RhoA in untreated HPB-ALL cells spreading on fibronectin demonstrated a diffuse staining pattern within the pseudopodia. In C3 treated cells, clusters of RhoA were pronounced and localized within the altered extensions.
conclusionsGTPase Rho is actively involved in the regulation of T lymphocyte morphology and motility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.