ArticleBMC genomics2003
STRP screening sets for the human genome at 5 cM density.
Article in BMC genomics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
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- Impact of restricted marital practices on genetic variation in an endogamous Gujarati group.American journal of physical anthropology · 2012Article
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- A genomic portrait of human microsatellite variation.Molecular biology and evolution · 2011Article
- Sequence determinants of human microsatellite variability.BMC genomics · 2009Article
- A genomewide comparison of population structure at STRPs and nearby SNPs in humans.Molecular biology and evolution · 2009Article
- Genetic epidemiology of subclinical cardiovascular disease in the diabetes heart study.Annals of human genetics · 2008Article
- Linkage disequilibrium between STRPs and SNPs across the human genome.American journal of human genetics · 2008Article
- Genetic structure of chimpanzee populations.PLoS genetics · 2007Article
- Low levels of genetic divergence across geographically and linguistically diverse populations from India.PLoS genetics · 2006Article
- A new locus for autosomal dominant intracranial aneurysm, ANIB4, maps to chromosome 5p15.2-14.3.Journal of medical genetics · 2006Article
- Clines, clusters, and the effect of study design on the inference of human population structure.PLoS genetics · 2005Article
- Evaluation of multiple displacement amplification in a 5 cM STR genome-wide scan.Nucleic acids research · 2005Article
- Genomewide scan for gout in taiwanese aborigines reveals linkage to chromosome 4q25.American journal of human genetics · 2004Article
- Informativeness of genetic markers for inference of ancestry.American journal of human genetics · 2003Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundShort tandem repeat polymorphisms (STRPs) are powerful tools for gene mapping and other applications. A STRP genome scan of 10 cM is usually adequate for mapping single gene disorders. However mapping studies involving genetically complex disorders and especially association (linkage disequilibrium) often require higher STRP density.
resultsWe report the development of two separate 10 cM human STRP Screening Sets (Sets 12 and 52) which span all chromosomes. When combined, the two Sets contain a total of 782 STRPs, with average STRP spacing of 4.8 cM, average heterozygosity of 0.72, and total sex-average coverage of 3535 cM. The current Sets are comprised almost entirely of STRPs based on tri- and tetranucleotide repeats. We also report correction of primer sequences for many STRPs used in previous Screening Sets. Detailed information for the new Screening Sets is available from our web site: http://research.marshfieldclinic.org/genetics.
conclusionOur new human STRP Screening Sets will improve the quality and cost effectiveness of genotyping for gene mapping and other applications.
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