ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Slow Na+ inactivation and variance adaptation in salamander retinal ganglion cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed, 131 citations in OpenAlex.
- The mysterious middlemen making your vision pop: understanding the function of amacrine cells.The Journal of physiology · 2025Review
- Stimulus-invariant aspects of the retinal code drive discriminability of natural scenes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Stimulus duration encoding occurs early in the moth olfactory pathway.Communications biology · 2024Article
- Spike desensitisation as a mechanism for high-contrast selectivity in retinal ganglion cells.Frontiers in cellular neuroscience · 2023Article
- Calcium/calmodulin-dependent protein kinase II associates with the KFrontiers in neuroanatomy · 2022Article
- What the salamander eye has been telling the vision scientist's brain.Seminars in cell & developmental biology · 2020Review
- High Contrast Allows the Retina to Compute More Than Just Contrast.Frontiers in cellular neuroscience · 2020Article
- Article
- The dynamic receptive fields of retinal ganglion cells.Progress in retinal and eye research · 2018Review
- Autophosphorylated CaMKII Facilitates Spike Propagation in Rat Optic Nerve.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Multiplexed computations in retinal ganglion cells of a single type.Nature communications · 2017Article
- Diversity in spatial scope of contrast adaptation among mouse retinal ganglion cells.Journal of neurophysiology · 2017Article
- Marked bias towards spontaneous synaptic inhibition distinguishes non-adapting from adapting layer 5 pyramidal neurons in the barrel cortex.Scientific reports · 2017Article
- Response dynamics of rat barrel cortex neurons to repeated sensory stimulation.Scientific reports · 2017Article
- A novel mechanism of cone photoreceptor adaptation.PLoS biology · 2017Article
- Article
- Neural Circuit Inference from Function to Structure.Current biology : CB · 2017Article
- Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells.eLife · 2016Article
- Efficient sensory cortical coding optimizes pursuit eye movements.Nature communications · 2016Article
- Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The retina adapts to the temporal contrast of the light inputs. One component of contrast adaptation is intrinsic to retinal ganglion cells: temporal contrast affects the variance of the synaptic inputs to ganglion cells, which alters the gain of spike generation. Here we show that slow Na+ inactivation is sufficient to produce the observed variance adaptation. Slow inactivation caused the Na+ current available for spike generation to depend on the past history of activity, both action potentials and subthreshold voltage variations. Recovery from slow inactivation required several hundred milliseconds. Increased current variance caused the threshold for spike generation to increase, presumably because of the decrease in available Na+ current. Simulations indicated that slow Na+ inactivation could account for the observed decrease in excitability. This suggests a simple picture of how ganglion cells contribute to contrast adaptation: (1) increasing contrast causes an increase in input current variance that raises the spike rate, and (2) the increased spike rate reduces the available Na+ current through slow inactivation, which feeds back to reduce excitability. Cells throughout the nervous system face similar problems of accommodating a large range of input signals; furthermore, the Na+ currents of many cells exhibit slow inactivation. Thus, adaptation mediated by feedback modulation of the Na+ current through slow inactivation could serve as a general mechanism to control excitability in spiking neurons.
Indexed as
Identifiers
12598639PMC6742238W2153654085What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.