ArticleThe American journal of pathology2003
Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways.
Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
91 citing papers in PubMed, 229 citations in OpenAlex.
- A single-center clinical trial evaluating topical propranolol for preventing stress-induced hair loss.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Trial
- Citrus limon-Derived Extracellular Vesicles Promote Hair Growth.Applied biochemistry and biotechnology · 2026Article
- Treatment With Ashwagandha-Derived Exosome-Like Nanovesicles Up-Regulates VEGF-A Production and Promotes Human Hair Growth Ex Vivo.Experimental dermatology · 2026Article
- Effects of a Botanical Extract Versus Minoxidil on Hair Loss-Associated Biomarkers: An In Vitro Study.Current issues in molecular biology · 2026Article
- Chemotherapy-Induced Alopecia Beyond Cytotoxicity: Hair Follicle Immune Privilege Collapse and JAK-STAT Signaling.International journal of molecular sciences · 2026Review
- Convergence of external and internal stressors on a stress-responsive enhancer of theProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Exploring the Potential Links between Telogen Effluvium, Alopecia Areata, Pressure-Induced Alopecia, and General Anesthesia: A Narrative Review.Dermatology and therapy · 2026Review
- Mast cells: "central regulatory hub" of neuro-endocrine-immune dysregulation in vitiligo.Frontiers in immunology · 2026Review
- Serotonin activates dermal papilla cells and promotes hair growth.Scientific reports · 2025Article
- Botulinum Toxin in the Treatment of Hair and Scalp Disorders: Current Evidence and Clinical Applications.Toxins · 2025Review
- Frontal Fibrosing Alopecia: An Update.American journal of clinical dermatology · 2025Review
- Anwuligan promotes the transition of the hair follicle cycle via the Wnt/β-catenin signaling pathway.Frontiers in pharmacology · 2025Article
- Natriuretic peptides modulate monocyte-derived Langerhans cell differentiation and promote a migratory phenotype.Frontiers in immunology · 2025Article
- Effects of Seasonality and Pregnancy on Hair Loss and Regrowth in Rhesus Macaques.Animals : an open access journal from MDPI · 2024Article
- The Biology and Genomics of Human Hair Follicles: A Focus on Androgenetic Alopecia.International journal of molecular sciences · 2024Review
- Systematic review: Impact of stem cells-based therapy, and platelet-rich plasma in hair loss and telogen effluvium related to COVID-19.Regenerative therapy · 2023Article
- Transmission infrared micro-spectroscopic study of individual human hair.Journal of biomedical optics · 2023Article
- Effects of the Complex ofNutrients · 2023Article
- Are hair cortisol levels dependent on hair growth rate? A pilot study in rhesus macaques.General and comparative endocrinology · 2023Article
- A catena between psychiatric disorders and non-scarring alopecias-A systematic review.Skin health and disease · 2023Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been much disputed whether or not stress can cause hair loss (telogen effluvium) in a clinically relevant manner. Despite the paramount psychosocial importance of hair in human society, this central, yet enigmatic and controversial problem of clinically applied stress research has not been systematically studied in appropriate animal models. We now show that psychoemotional stress indeed alters actual hair follicle (HF) cycling in vivo, ie, prematurely terminates the normal duration of active hair growth (anagen) in mice. Further, inflammatory events deleterious to the HF are present in the HF environment of stressed mice (perifollicular macrophage cluster, excessive mast cell activation). This provides the first solid pathophysiological mechanism for how stress may actually cause telogen effluvium, ie, by hair cycle manipulation and neuroimmunological events that combine to terminate anagen. Furthermore, we show that most of these hair growth-inhibitory effects of stress can be reproduced by the proteotypic stress-related neuropeptide substance P in nonstressed mice, and can be counteracted effectively by co-administration of a specific substance P receptor antagonist in stressed mice. This offers the first convincing rationale how stress-induced hair loss in men may be pharmacologically managed effectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.