ArticleThe American journal of pathology2003
High-resolution analysis of paraffin-embedded and formalin-fixed prostate tumors using comparative genomic hybridization to genomic microarrays.
Article in The American journal of pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Single nucleus DNA sequencing of flow sorted archived frozen and formalin fixed paraffin embedded solid tumors.BMC genomics · 2024Article
- Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism.Nature communications · 2018Article
- Recurrent genomic alterations in sequential progressive leukoplakia and oral cancer: drivers of oral tumorigenesis?Human molecular genetics · 2014Article
- Chromosomal and genetic imbalances in Chinese patients with rhabdomyosarcoma detected by high-resolution array comparative genomic hybridization.International journal of clinical and experimental pathology · 2014Article
- Article
- The zinc finger transcription factor ZKSCAN3 promotes prostate cancer cell migration.The international journal of biochemistry & cell biology · 2012Article
- Article
- DNA fragmentation simulation method (FSM) and fragment size matching improve aCGH performance of FFPE tissues.PloS one · 2012Article
- Genome-wide comparison of paired fresh frozen and formalin-fixed paraffin-embedded gliomas by custom BAC and oligonucleotide array comparative genomic hybridization: facilitating analysis of archival gliomas.Acta neuropathologica · 2011Article
- A group of genome-based biomarkers that add to a Kattan nomogram for predicting progression in men with high-risk prostate cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010Article
- Whole genome amplification for array comparative genomic hybridization using DNA extracted from formalin-fixed, paraffin-embedded histological sections.The Journal of molecular diagnostics : JMD · 2009Article
- High resolution oligonucleotide CGH using DNA from archived prostate tissue.The Prostate · 2007Article
- Article
- An approach to the validation of novel molecular markers of breast cancer via TMA-based FISH scanning.Journal of molecular histology · 2007Article
- Matrix-comparative genomic hybridization from multicenter formalin-fixed paraffin-embedded colorectal cancer tissue blocks.BMC cancer · 2007Article
- Expression analysis of imbalanced genes in prostate carcinoma using tissue microarrays.British journal of cancer · 2007Article
- Genomic profiling of hormone-naïve lymph node metastases in patients with prostate cancer.Neoplasia (New York, N.Y.) · 2006Article
- Article
- Comparison of chromosomal and array-based comparative genomic hybridization for the detection of genomic imbalances in primary prostate carcinomas.Molecular cancer · 2006Article
- Glioma test array for use with formalin-fixed, paraffin-embedded tissue: array comparative genomic hybridization correlates with loss of heterozygosity and fluorescence in situ hybridization.The Journal of molecular diagnostics : JMD · 2006Article
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Authors and funding
17 authors.
Funding
Abstract
We have used prostate cancer, the most commonly diagnosed noncutaneous neoplasm among men, to investigate the feasibility of performing genomic array analyses of archival tissue. Prostate-specific antigen and a biopsy Gleason grade have not proven to be accurate in predicting clinical outcome, yet they remain the only accepted biomarkers for prostate cancer. It is likely that distinct spectra of genomic alterations underlie these phenotypic differences, and that once identified, may be used to differentiate between indolent and aggressive tumors. Array comparative genomic hybridization allows quantitative detection and mapping of copy number aberrations in tumors and subsequent associations to be made with clinical outcome. Archived tissues are needed to have patients with sufficient clinical follow-up. In this report, 20 formalin-fixed and paraffin-embedded prostate cancer samples originating from 1986 to 1996 were studied. We present a straightforward protocol and demonstrate the utility of archived tissue for array comparative genomic hybridization with a 2400 element BAC array that provides high-resolution detection of both deletions and amplifications.
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