Evidence map›Paper›PMID 12596903›Full record

ReviewCurrent topics in microbiology and immunology2003

Chromatin proteins are determinants of centromere function.

J A Sharp, P D Kaufman

Abstract readReview
In one paragraph

Review in Current topics in microbiology and immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  10. Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation.Proceedings of the National Academy of Sciences of the United States of America · 2005
    Article
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

J A SharpUniversity of California, Berkeley, Stanley Hall, Mail Code 3206, Berkeley, CA 94720, USA. jsharp@uclink4.berkeley.edu
P D Kaufman

Funding

Regulation of repetitive chromatin structures during the human cell cycleR01GM055712 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KAUFMAN, PAUL D. · 1997 to 2014
$5.1M
NIGMS NIH HHS 1 R01 GM55712NIGMS NIH HHS R01 GM055712
6 · The paper itself

Abstract

Recent advances in the identification of molecular components of centromeres have demonstrated a crucial role for chromatin proteins in determining both centromere identity and the stability of kinetochore-microtubule attachments. Although we are far from a complete understanding of the establishment and propagation of centromeres, this review seeks to highlight the contribution of histones, histone deposition factors, histone modifying enzymes, and heterochromatin proteins to the assembly of this sophisticated, highly specialized chromatin structure. First, an overview of DNA sequence elements at centromeric regions will be presented. We will then discuss the contribution of chromatin to kinetochore function in budding yeast, and pericentric heterochromatin domains in other eukaryotic systems. We will conclude with discussion of specialized nucleosomes that direct kinetochore assembly and propagation of centromere-defining chromatin domains.

Indexed as

AnimalsCentromereChromatinDrosophilaGene Expression RegulationHumansNucleoproteinsSaccharomyces cerevisiaeSchizosaccharomycesChromatinNucleoproteins

Identifiers

PMID12596903
PMCPMC1283066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.