ArticleGenes and immunity2003
Evidence of at least two type 1 diabetes susceptibility genes in the HLA complex distinct from HLA-DQB1, -DQA1 and -DRB1.
Article in Genes and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Conditional meta-analysis stratifying on detailed HLA genotypes identifies a novel type 1 diabetes locus around TCF19 in the MHC.Human genetics · 2011Pooled it
- A genetic risk score for thyroid peroxidase antibodies associates with clinical thyroid disease in community-based populations.The Journal of clinical endocrinology and metabolism · 2015Article
- Genetics of the HLA region in the prediction of type 1 diabetes.Current diabetes reports · 2011Review
- Pervasive haplotypic variation in the spliceo-transcriptome of the human major histocompatibility complex.Genome research · 2011Article
- Novel gene associations in type 1 diabetes.Current diabetes reports · 2010Article
- Genetic variation within the HLA class III influences T1D susceptibility conferred by high-risk HLA haplotypes.Genes and immunity · 2010Article
- The type 1 diabetes - HLA susceptibility interactome--identification of HLA genotype-specific disease genes for type 1 diabetes.PloS one · 2010Article
- Exploring the diabetogenicity of the HLA-B18-DR3 CEH: independent association with T1D genetic risk close to HLA-DOA.Genes and immunity · 2009Article
- Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex.Genes and immunity · 2009Article
- Genetic variants of the HLA-A, HLA-B and AIF1 loci show independent associations with type 1 diabetes in Norwegian families.Genes and immunity · 2009Article
- Effect of linkage status of affected sib-pairs on the search for novel type 1 diabetes susceptibility genes in the HLA complex.Diabetes, obesity & metabolism · 2009Article
- Identification of T1D susceptibility genes within the MHC region by combining protein interaction networks and SNP genotyping data.Diabetes, obesity & metabolism · 2009Article
- Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1.Diabetes, obesity & metabolism · 2009Article
- Three microsatellites from the T1DGC MHC data set show highly significant association with type 1 diabetes, independent of the HLA-DRB1, -DQA1 and -DQB1 genes.Diabetes, obesity & metabolism · 2009Article
- Conditional analyses on the T1DGC MHC dataset: novel associations with type 1 diabetes around HLA-G and confirmation of HLA-B.Genes and immunity · 2009Article
- HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families.Diabetes · 2008Article
- The HLA Region and Autoimmune Disease: Associations and Mechanisms of Action.Current genomics · 2007Article
- Conserved extended haplotypes discriminate HLA-DR3-homozygous Basque patients with type 1 diabetes mellitus and celiac disease.Genes and immunity · 2006Article
- Extreme genetic risk for type 1A diabetes.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Linkage disequilibrium and haplotype blocks in the MHC vary in an HLA haplotype specific manner assessed mainly by DRB1*03 and DRB1*04 haplotypes.Genes and immunity · 2006Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Susceptibility to, and protection against development of type 1 diabetes (T1D) are primarily associated with the highly polymorphic exon 2 sequences of the HLA class II genes: DQB1, DQA1 and DRB1. However, several studies have also suggested that additional genes in the HLA complex influence T1D risk, albeit to a lesser degree than the class II genes. We have previously shown that allele 3 of microsatellite marker D6S2223, 4.9 Mb telomeric of DQ in the extended class I region, is associated with a reduction in risk conferred by the DQ2-DR3 haplotype. Here we replicate this finding in two populations from Sweden and France. We also show that markers in the HLA class II, III and centromeric class I regions contribute to the DQ2-DR3 associated risk of T1D, independently of linkage disequilibrium (LD) with both the DQ/DR genes and the D6S2223 associated gene. The associated marker alleles are carried on the DQ2-DR3-B18 haplotype in a region of strong LD. By haplotype mapping, we have located the most likely location for this second DQ2-DR3 haplotype-modifying locus to the 2.35 Mb region between HLA-DOB and marker D6S2702, located 970 kb telomeric of HLA-B.
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