ArticleInfection and immunity2003
Effects of respiratory Mycoplasma pneumoniae infection on allergen-induced bronchial hyperresponsiveness and lung inflammation in mice.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 118 citations in OpenAlex.
- Innate and adaptive immunity pathways linking Mycoplasma pneumoniae to pediatric asthma phenotypes.European journal of pediatrics · 2026Review
- Eosinophil-derived neurotoxin as a biomarker to predict the development of asthma after respiratory infection in infant.Translational pediatrics · 2026Article
- Immune dysregulation inFrontiers in immunology · 2026Review
- A comprehensive review ofFrontiers in medicine · 2024Review
- The novel pleuromutilin derivative 22-((4-((4-nitrophenyl)acetamido)phenyl)thio)deoxy pleuromutilin possesses robust anti-mycoplasma activity bothFrontiers in pharmacology · 2024Article
- Tollip deficiency exaggerates airway type 2 inflammation in mice exposed to allergen and influenza A virus: role of the ATP/IL-33 signaling axis.Frontiers in immunology · 2023Article
- Association of atopy with disease severity in children withFrontiers in pediatrics · 2023Article
- Pathogens and Pathogenesis in Wheezing Diseases in Children Under 6.Frontiers in oncology · 2022Article
- Chronic infection with Chlamydia pneumoniae in asthma: a type-2 low infection related phenotype.Respiratory research · 2021Article
- Serum Cytokines and FeNO in School-Aged Children with Mycoplasma pneumoniae Pneumonia.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Th17/IL-17 Axis Regulated by Airway Microbes Get Involved in the Development of Asthma.Current allergy and asthma reports · 2020Review
- Overproduction of growth differentiation factor 15 promotes human rhinovirus infection and virus-induced inflammation in the lung.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Toll-Interacting Protein, Tollip, Inhibits IL-13-Mediated Pulmonary Eosinophilic Inflammation in Mice.Journal of innate immunity · 2018Article
- A novel mouse model of conditional IRAK-M deficiency in myeloid cells: application in lung Pseudomonas aeruginosa infection.Innate immunity · 2017Article
- Temporal Stability and the Effect of Transgenerational Transfer on Fecal Microbiota Structure in a Long Distance Migratory Bird.Frontiers in microbiology · 2017Article
- Tollip SNP rs5743899 modulates human airway epithelial responses to rhinovirus infection.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2016Article
- A Compendium for Mycoplasma pneumoniae.Frontiers in microbiology · 2016Review
- Therapeutic Effects of α1-Antitrypsin on Psedumonas aeruginosa Infection in ENaC Transgenic Mice.PloS one · 2015Article
- Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner.Infection and immunity · 2014Article
- The efficacy of glucocorticoid on macrolide resistant Mycoplasma pneumonia in children.Allergy, asthma & immunology research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Airway mycoplasma infection may be associated with asthma pathophysiology. However, the direct effects of mycoplasma infection on asthma remain unknown. Using a murine allergic-asthma model, we evaluated the effects of different timing of airway Mycoplasma pneumoniae infection on bronchial hyperresponsiveness (BHR), lung inflammation, and the protein levels of Th1 (gamma interferon [IFN-gamma]) and Th2 (interleukin 4 [IL-4]) cytokines in bronchoalveolar lavage fluid. When mycoplasma infection occurred 3 days before allergen (ovalbumin) sensitization and challenge, the infection reduced the BHR and inflammatory-cell influx into the lung. This was accompanied by a significant induction of Th1 responses (increased IFN-gamma and decreased IL-4 production). Conversely, when mycoplasma infection occurred 2 days after allergen sensitization and challenge, the infection initially caused a temporary reduction of BHR and then increased BHR, lung inflammation, and IL-4 levels. Our data suggest that mycoplasma infection could modulate both physiological and immunological responses in the murine asthma model. Our animal models may also provide a new means to understand the role of infection in asthma pathogenesis and give evidence for the asthma hygiene hypothesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.