ArticleInfection and immunity2003
Localized eosinophil degranulation mediates disease in tropical pulmonary eosinophilia.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner.PLoS pathogens · 2024Article
- Induction of Siglec-FFrontiers in immunology · 2023Article
- Eosinophils and helminth infection: protective or pathogenic?Seminars in immunopathology · 2021Review
- "NETs and EETs, a Whole Web of Mess".Microorganisms · 2020Review
- Microfilaria-dependent thoracic pathology associated with eosinophilic and fibrotic polyps in filaria-infected rodents.Parasites & vectors · 2020Article
- 1,6-O,O-Diacetylbritannilactone Inhibits Eotaxin-1 and ALOX15 Expression Through Inactivation of STAT6 in A549 Cells.Inflammation · 2017Article
- Allergic Sensitization Underlies Hyperreactive Antigen-Specific CD4+ T Cell Responses in Coincident Filarial Infection.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Reduced Leukocyte Infiltration in Absence of Eosinophils Correlates with Decreased Tissue Damage and Disease Susceptibility in ΔdblGATA Mice during Murine Neurocysticercosis.PLoS neglected tropical diseases · 2016Article
- Lipoxins: nature's way to resolve inflammation.Journal of inflammation research · 2015Review
- Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway.Molecules (Basel, Switzerland) · 2014Article
- Eosinophils are important for protection, immunoregulation and pathology during infection with nematode microfilariae.PLoS pathogens · 2014Article
- Tropical pulmonary eosinophilia--a review.The Indian journal of medical research · 2013Review
- Eosinophilic pneumonias.Clinical microbiology reviews · 2012Review
- Cardiac involvement with parasitic infections.Clinical microbiology reviews · 2010Review
- Cardiac manifestations of parasitic infections part 3: pericardial and miscellaneous cardiopulmonary manifestations.Clinical cardiology · 2007Review
- The innate allergenicity of helminth parasites.Clinical reviews in allergy & immunology · 2004Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
To explore the mechanisms underlying the eosinophil-mediated inflammation of tropical pulmonary eosinophilia (TPE), bronchoalveolar lavage (BAL) fluid, serum, and supernatants from pulmonary and blood leukocytes (WBC) from patients with acute TPE (n = 6) were compared with those obtained from healthy uninfected individuals (n = 4) and from patients with asthma (n = 4) or elephantiasis (n = 5). Although there were no significant differences in the levels of interleukin-4 (IL-4), IL-5, IL-13, eotaxin, granulocyte-macrophage colony-stimulating factor, RANTES, or eosinophil cationic protein, there was a marked increase in eosinophil-derived neurotoxin (EDN) both systemically and in the lungs of individuals with TPE compared to each of the control groups (P < 0.02). Moreover, there was a compartmentalization of this response, with EDN levels being higher in the BAL fluid than in the serum (P < 0.02). Supernatants from WBC from either whole blood or BAL cells were examined for chemokines, cytokines, eosinophil degranulation products, and arachidonic acid metabolites. Of the many mediators examined-particularly those associated with eosinophil trafficking-only EDN (in BAL fluid and WBC) and MIP-1alpha (in WBC) levels were higher for TPE patients than for the non-TPE control groups (P < 0.02). These data suggest it is the eosinophilic granular protein EDN, an RNase capable of damaging the lung epithelium, that plays the most important role in the pathogenesis of TPE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.