ArticleInfection and immunity2003
Phenotypic switching in Mycoplasma gallisepticum hemadsorption is governed by a high-frequency, reversible point mutation.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Designing of novel chimeric PvpA-pMGA protein of Mycoplasma gallisepticum, applicable for indirect ELISA.Journal, genetic engineering & biotechnology · 2022Article
- The expression of GapA and CrmA correlates with the Mycoplasma gallisepticum in vitro infection process in chicken TOCs.Veterinary research · 2022Article
- Multiple differences in pathogen-host cell interactions following a bacterial host shift.Scientific reports · 2020Article
- TheInfection and immunity · 2017Article
- In-silico prediction and deep-DNA sequencing validation indicate phase variation in 115 Neisseria meningitidis genes.BMC genomics · 2016Article
- First identification of proteins involved in motility of Mycoplasma gallisepticum.Veterinary research · 2014Article
- Role of the GapA and CrmA cytadhesins of Mycoplasma gallisepticum in promoting virulence and host colonization.Infection and immunity · 2013Article
- Development of a site-directed integration plasmid for heterologous gene expression in Mycoplasma gallisepticum.PloS one · 2013Article
- Mycoplasma gallisepticum invades chicken erythrocytes during infection.Infection and immunity · 2008Article
- Mycoplasma genitalium P140 and P110 cytadhesins are reciprocally stabilized and required for cell adhesion and terminal-organelle development.Journal of bacteriology · 2006Article
- Resistance to antimicrobial peptides and stress response in Mycoplasma pulmonis.Antimicrobial agents and chemotherapy · 2005Article
- First steps towards the genetic manipulation of Mycoplasma agalactiae and Mycoplasma bovis using the transposon Tn4001mod.International journal of medical microbiology : IJMM · 2005Article
- Role of phagocytosis in the virulence of Cryptococcus neoformans.Eukaryotic cell · 2004Review
- Phase and antigenic variation in bacteria.Clinical microbiology reviews · 2004Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycoplasma gallisepticum is a flask-shaped organism that commonly induces chronic respiratory disease in chickens and infectious sinusitis in turkeys. Phenotypic switching in M. gallisepticum hemadsorption (HA) was found to correlate with phase variation of the GapA cytadhesin concurrently with that of the CrmA protein, which exhibits cytadhesin-related features and is encoded by a gene located downstream of the gapA gene as part of the same transcription unit. In clones derived from strain R(low), detailed genetic analyses further revealed that on-off switching in GapA expression is governed by a reversible base substitution occurring at the beginning of the gapA structural gene. In HA(-) variants, this event generates a stop codon that results in the premature termination of GapA translation and consequently affects the expression of CrmA. Sequences flanking the mutation spot do not feature any repeated motifs that could account for error-prone mutation via DNA slippage and the exact mechanism underlying this high-frequency mutational event remains to be elucidated. An HA(-) mutant deficient in producing CrmA, mHAD3, was obtained by disrupting the crmA gene by using transposition mutagenesis. Despite a fully functional gapA gene, the amount of GapA detected in this mutant was considerably lower than in HA(+) clonal variants, suggesting that, in absence of CrmA, GapA might be subjected to a higher turnover.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.