ArticleInfection and immunity2003
Macrophage migration inhibitory factor plays a critical role in mediating protection against the helminth parasite Taenia crassiceps.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 70 citations in OpenAlex.
- Macrophage migration inhibitory factor promotes eosinophil accumulation and tissue remodeling in eosinophilic esophagitis.Mucosal immunology · 2015Trial
- MIF Deficiency Modulates Gut Microbiota Composition and Promotes Colitis-Associated Colorectal Cancer in a Murine Model.Current issues in molecular biology · 2026Article
- Emerging Role of Splenic Macrophage in Malaria Pathogenesis and Immunity.Immunity, inflammation and disease · 2025Review
- Crystal structure of N-terminally hexahistidine-tagged Onchocerca volvulus macrophage migration inhibitory factor-1.Acta crystallographica. Section F, Structural biology communications · 2024Article
- Differential Protein Expression ofPathogens (Basel, Switzerland) · 2023Article
- The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF).Mucosal immunology · 2022Article
- Macrophage migration inhibitory factor contributes to immunopathogenesis duringFrontiers in cellular and infection microbiology · 2022Article
- Inhibition of Macrophage Migration Inhibitory Factor Activity Attenuates Haemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats.Frontiers in immunology · 2022Article
- The Role of MIF on Eosinophil Biology and Eosinophilic Inflammation.Clinical reviews in allergy & immunology · 2020Review
- Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse.Journal of immunology research · 2018Review
- Macrophage migration inhibitory factor deficiency enhances immune response to Nippostrongylus brasiliensis.Mucosal immunology · 2017Article
- EXPERIMENTAL SUBCUTANEOUS CYSTICERCOSIS BY Taenia crassiceps IN BALB/c AND C57BL/6 MICE.Revista do Instituto de Medicina Tropical de Sao Paulo · 2016Article
- Article
- E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo.Scientific reports · 2015Article
- Novel anti-inflammatory activity of epoxyazadiradione against macrophage migration inhibitory factor: inhibition of tautomerase and proinflammatory activities of macrophage migration inhibitory factor.The Journal of biological chemistry · 2012Article
- Macrophage migration inhibitory factor: a downregulator of early T cell-dependent IFN-gamma responses in Plasmodium chabaudi adami (556 KA)-infected mice.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Effect of macrophage migration inhibitory factor (MIF) in human placental explants infected with Toxoplasma gondii depends on gestational age.The American journal of pathology · 2011Article
- TLR2 mediates immunity to experimental cysticercosis.International journal of biological sciences · 2011Article
- A small-molecule inhibitor of macrophage migration inhibitory factor for the treatment of inflammatory disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- The unexpected role for the aryl hydrocarbon receptor on susceptibility to experimental toxoplasmosis.Journal of biomedicine & biotechnology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
To determine the role of endogenous migration inhibitory factor (MIF) in regulation of immune response during murine cysticercosis caused by the helminth parasite Taenia crassiceps, we analyzed the course of T. crassiceps infection in MIF(-/-) BALB/c mice. MIF(-/-) mice were highly susceptible to T. crassiceps and developed significantly higher parasite loads compared to similarly infected MIF(+/+) mice. Throughout the course of infection, Taenia crassiceps soluble antigen-stimulated spleen cells from both MIF(+/+) and MIF(-/-) mice produced significant and comparable levels of interleukin-4 (IL-4), but those from MIF(-/-) mice produced significantly more IL-13, as well as gamma interferon (IFN-gamma), suggesting that the susceptibility of MIF(-/-) mice to T. crassiceps was not due to the lack of IFN-gamma production. Interestingly, low levels of both total and specific immunoglobulin G2a were observed in MIF(-/-) cysticercotic mice despite the high IFN-gamma levels; in addition, peritoneal macrophages obtained from T. crassiceps-infected MIF(-/-) mice at different time points failed to respond efficiently to stimulation in vitro with lipopolysaccharide plus IFN-gamma and produced significantly lower levels of IL-12, tumor necrosis factor alpha, and NO compared to those from MIF(+/+) mice. These findings demonstrate that MIF plays a critical role in mediating protection against T. crassiceps in vivo. Moreover, these findings also suggest that impaired macrophage function rather than the lack of Th1 development may be responsible for mediating susceptibility to T. crassiceps.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.