ArticleInfection and immunity2003
Polymorphic membrane protein H has evolved in parallel with the three disease-causing groups of Chlamydia trachomatis.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 62 citations in OpenAlex.
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- Rapid expansion of lymphogranuloma venereum infections with fast diversification and spread ofMicrobiology spectrum · 2024Article
- Sequence, structure prediction, and epitope analysis of the polymorphic membrane protein family in Chlamydia trachomatis.PloS one · 2024Article
- Genetic Characterization of Non-International journal of molecular sciences · 2023Article
- Occurrence ofPathogens (Basel, Switzerland) · 2021Article
- Expression and localization of predicted inclusion membrane proteins in Chlamydia trachomatis.Infection and immunity · 2015Article
- Trachoma and Ocular Chlamydial Infection in the Era of Genomics.Mediators of inflammation · 2015Review
- Chlamydia trachomatis control requires a vaccine.Vaccine · 2013Review
- Role for chlamydial inclusion membrane proteins in inclusion membrane structure and biogenesis.PloS one · 2013Article
- The alternative translational profile that underlies the immune-evasive state of persistence in Chlamydiaceae exploits differential tryptophan contents of the protein repertoire.Microbiology and molecular biology reviews : MMBR · 2012Review
- Chlamydia muridarum T cell antigens and adjuvants that induce protective immunity in mice.Infection and immunity · 2012Article
- Nucleotide and phylogenetic analyses of the Chlamydia trachomatis ompA gene indicates it is a hotspot for mutation.BMC research notes · 2012Article
- Evolution and conservation of predicted inclusion membrane proteins in chlamydiae.Comparative and functional genomics · 2012Article
- Phylogenetic analysis of Chlamydia trachomatis Tarp and correlation with clinical phenotype.Infection and immunity · 2010Article
- Protective immunity to Chlamydia trachomatis genital infection: evidence from human studies.The Journal of infectious diseases · 2010Review
- Chlamydia trachomatis strains and virulence: rethinking links to infection prevalence and disease severity.The Journal of infectious diseases · 2010Review
- Comprehensive in silico prediction and analysis of chlamydial outer membrane proteins reflects evolution and life style of the Chlamydiae.BMC genomics · 2009Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlamydia trachomatis is a human pathogen causing trachoma, urogenital disease, and lymphogranuloma venereum (LGV). A family of nine polymorphic membrane protein genes (pmpA to pmpI), resembling autotransporter proteins, has recently been discovered in C. trachomatis. pmp genes are large and predicted to be outer membrane proteins. We hypothesized that they would contain useful nucleotide sequence variability for epidemiologic studies. Since sequence information is available only for serovars D and L2, we sought to determine the amount of diversity within an individual pmp gene among serovars. We used restriction fragment length polymorphism (RFLP) analysis as a primary screen to assess the amount of sequence divergence among the pmp genes for serovars A to L3 of C. trachomatis. RFLP analysis showed little variation for some of the genes, such as pmpA, but substantial variation in others, such as pmpI. pmpH and pmpE yielded RFLP patterns that clustered the 15 serovars into ocular, urogenital, and LGV groups, and both proteins have been localized to the outer membrane. Therefore, we chose to sequence pmpE, pmpH, and pmpI from each of the 15 serovars. Evolutionary analysis showed three distinct divergence patterns. PmpI was least variable, resulting in an ambiguous evolutionary pattern. PmpE showed a high degree of diversity in the ocular strains compared to the other strains. Finally, the evolution of PmpH shows three groups that reflect disease groups, suggesting this protein may play a role in pathogenesis.
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