ArticleInfection and immunity2003
Identification of genetic loci required for capsular expression in Vibrio vulnificus.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- Comprehensive genomic and evolutionary analysis of biofilm matrix clusters and proteins in themSystems · 2025Article
- Structure, Function, and Regulation of the Essential Virulence Factor Capsular Polysaccharide ofInternational journal of molecular sciences · 2020Review
- Resistance integrons; A Mini review.Caspian journal of internal medicine · 2019Review
- Genetic and Molecular Basis of Kingella kingae Encapsulation.Infection and immunity · 2016Article
- Integrons: past, present, and future.Microbiology and molecular biology reviews : MMBR · 2014Review
- Genetic analysis and prevalence studies of the brp exopolysaccharide locus of Vibrio vulnificus.PloS one · 2014Article
- The function of integron-associated gene cassettes in Vibrio species: the tip of the iceberg.Frontiers in microbiology · 2013Review
- Deletion of integron-associated gene cassettes impact on the surface properties of Vibrio rotiferianus DAT722.PloS one · 2013Article
- The regulator HlyU, the repeat-in-toxin gene rtxA1, and their roles in the pathogenesis of Vibrio vulnificus infections.MicrobiologyOpen · 2012Review
- Light-scattering sensor for real-time identification of Vibrio parahaemolyticus, Vibrio vulnificus and Vibrio cholerae colonies on solid agar plate.Microbial biotechnology · 2012Article
- Identification and characterization of a novel outer membrane protein receptor required for hemin utilization in Vibrio vulnificus.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2012Article
- The influence of the accessory genome on bacterial pathogen evolution.Mobile genetic elements · 2011Article
- Vibrio vulnificus: disease and pathogenesis.Infection and immunity · 2009Review
- HlyU acts as an H-NS antirepressor in the regulation of the RTX toxin gene essential for the virulence of the human pathogen Vibrio vulnificus CMCP6.Molecular microbiology · 2009Article
- Vibrio biofilms: so much the same yet so different.Trends in microbiology · 2009Review
- Molecular analysis of the Enterobacter sakazakii O-antigen gene locus.Applied and environmental microbiology · 2008Article
- Further characterization of Vibrio vulnificus rugose variants and identification of a capsular and rugose exopolysaccharide gene cluster.Infection and immunity · 2008Article
- Identification of a Wzy polymerase required for group IV capsular polysaccharide and lipopolysaccharide biosynthesis in Vibrio vulnificus.Infection and immunity · 2007Article
- The HlyU protein is a positive regulator of rtxA1, a gene responsible for cytotoxicity and virulence in the human pathogen Vibrio vulnificus.Infection and immunity · 2007Article
- The capsule polysaccharide structure and biogenesis for non-O1 Vibrio cholerae NRT36S: genes are embedded in the LPS region.BMC microbiology · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transposon mutagenesis of an encapsulated, virulent strain of Vibrio vulnificus 1003(O) led to the identification of four genetic regions that are essential to capsular polysaccharide (CPS) expression and virulence. Of the four regions, three are believed to be part of a capsule gene locus comprised of biosynthesis, polymerization, and transport genes clustered on a single chromosomal fragment. Genes indicating a Wzy-dependent system of polymerization and transmembrane export are present, suggesting that the CPS of V. vulnificus is lipid linked. The fourth region, while it contains a gene essential for CPS expression, is characteristic of an integron-gene cassette region, similar to the super integron of V. cholerae. It is not believed to be part of a CPS gene locus and is located in a region of the chromosome separate from the putative CPS loci. It is comprised of open reading frames (ORFs) carrying genes of unknown function surrounded by direct repeats. This region also contains IS492, an insertion sequence located numerous times throughout a region of the genome, demonstrating a restriction fragment length polymorphism among an encapsulated and nonencapsulated morphotype of V. vulnificus. Collectively, 22 ORFs were recognized: 13 capsule synthesis genes, 4 insertion sequences, 1 truncated biosynthesis gene, and 4 genes of unknown function. This study has led to the identification of previously unrecognized genetic loci that may help to increase the understanding of capsular genetics and antigenic diversity among V. vulnificus strains.
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