Evidence map›Paper›PMID 12594924›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2003

Parasite plastids: maintenance and functions.

R J M Iain Wilson, K Rangachari, J W Saldanha, L Rickman, R S Buxton, J F Eccleston

Open access · greenAbstract read
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Coordination of plastid and nuclear gene expression.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2003
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

R J M Iain WilsonNational Institute for Medical Research, Mill Hill, London NW7 1AA, UK. rwilson@nimr.mrc.ac.uk
K Rangachari
J W Saldanha
L Rickman
R S Buxton
J F Eccleston

Funding

Medical Research Council MC_U117585867Medical Research Council U.1175.02.002.00013 (85867)
6 · The paper itself

Abstract

Malaria and related parasites retain a vestigial, but biosynthetically active, plastid organelle acquired far back in evolution from a red algal cell. The organelle appears to be essential for parasite transmission from cell to cell and carries the smallest known plastid genome. Why has this genome been retained? The genes it carries seem to be dedicated to the expression of just two "housekeeping" genes. We speculate that one of these, called ycf24 in plants and sufB in bacteria, is tied to an essential "dark" reaction of the organelle--fatty acid biosynthesis. "Ball-park" clues to the function of bacterial suf genes have emerged only recently and point to the areas of iron homeostasis, [Fe-S] cluster formation and oxidative stress. We present experimental evidence for a physical interaction between SufB and its putative partner SufC (ycf16). In both malaria and plants, SufC is encoded in the nucleus and specifies an ATPase that is imported into the plastid.

Indexed as

Evolution, MolecularAmino Acid SequenceAnimalsBacterial ProteinsModels, MolecularMolecular Sequence DataOxidative StressPlant ProteinsPlasmodium falciparumPlastidsProtozoan ProteinsBacterial ProteinsPlant ProteinsProtozoan Proteins

Identifiers

PMID12594924
PMCPMC1693094
OpenAlexW2068628756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.