ArticleProtein science : a publication of the Protein Society2003
Enhanced correction methods for hydrogen exchange-mass spectrometric studies of amyloid fibrils.
Article in Protein science : a publication of the Protein Society, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- The role of probiotics, prebiotics, and postbiotics: cellular and molecular pathways activated on glial cells in Alzheimer's disease.Frontiers in neuroscience · 2025Review
- Early-stage mapping of macromolecular content in APPFrontiers in aging neuroscience · 2023Article
- Amyloid beta: structure, biology and structure-based therapeutic development.Acta pharmacologica Sinica · 2017Review
- Two distinct β-sheet structures in Italian-mutant amyloid-beta fibrils: a potential link to different clinical phenotypes.Cellular and molecular life sciences : CMLS · 2015Article
- Intrinsic structural heterogeneity and long-term maturation of amyloid β peptide fibrils.ACS chemical neuroscience · 2013Article
- Abeta(1-40) forms five distinct amyloid structures whose beta-sheet contents and fibril stabilities are correlated.Journal of molecular biology · 2010Article
- Mass spectrometry and the amyloid problem--how far can we go in the gas phase?Journal of the American Society for Mass Spectrometry · 2010Article
- Complementary peptide sequence coverage using alternative enzymes for on-line digestion with a triaxial electrospray probe.Journal of the American Society for Mass Spectrometry · 2009Article
- Structural differences between Abeta(1-40) intermediate oligomers and fibrils elucidated by proteolytic fragmentation and hydrogen/deuterium exchange.Biophysical journal · 2009Article
- Simultaneous monitoring of peptide aggregate distributions, structure, and kinetics using amide hydrogen exchange: application to Abeta(1-40) fibrillogenesis.Biotechnology and bioengineering · 2008Article
- A triaxial probe for on-line proteolysis coupled with hydrogen/deuterium exchange-electrospray mass spectrometry.Journal of the American Society for Mass Spectrometry · 2007Article
- Nanotools for megaproblems: probing protein misfolding diseases using nanomedicine modus operandi.Journal of proteome research · 2006Review
- Structural properties of Abeta protofibrils stabilized by a small molecule.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Using mass spectrometry-based methods to understand amyloid formation and inhibition of alpha-synuclein and amyloid beta.Mass spectrometry reviewsReview
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3 authors at 1 institution in 1 country.
Funding
Abstract
We describe methods for minimization of and correction for artifactual forward and backward exchange occurring during hydrogen exchange-mass spectrometric (HX-MS) studies of amyloid fibrils of the Abeta(1-40) peptide. The quality of the corrected data obtained using published and new correction algorithms is evaluated quantitatively. Using the new correction methods, we have determined that 20.1 +/- 1.4 of the 39 backbone amide hydrogens in Abeta(1-40) exchange with deuteriums in 100 h when amyloid fibrils of this peptide are suspended in D(2)O. These data reinforce our previous conclusions based on uncorrected data that amyloid fibrils contain a rigid protective core structure that involves only about half of the Abeta backbone amides. The methods developed here should be of general value for HX-MS studies of amyloid fibrils and other protein aggregates.
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