Evidence map›Paper›PMID 12591999›Full record

ReviewRNA (New York, N.Y.)2003

Uridine insertion/deletion RNA editing in trypanosome mitochondria: a complex business.

Larry Simpson, Sandro Sbicego, Ruslan Aphasizhev

Open access · bronzeAbstract readReview
In one paragraph

Review in RNA (New York, N.Y.), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 166 citations in OpenAlex.

  1. Article
  2. Article
  3. Mitochondrial DNA Structure inPathogens (Basel, Switzerland) · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. The Complete Mitochondrial DNA ofFrontiers in cellular and infection microbiology · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Humanizing glycosylation pathways in eukaryotic expression systems.World journal of microbiology & biotechnology · 2017
    Review
  17. Article
  18. Article
  19. Article
  20. Inhibitors of RNA editing as potential chemotherapeutics against trypanosomatid pathogens.International journal for parasitology. Drugs and drug resistance · 2012
    Review

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Larry SimpsonHoward Hughes Medical Institute and Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California 90095, USA. simpson@kdna.ucla.edu
Sandro Sbicego
Ruslan Aphasizhev
Howard Hughes Medical Institute · USUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The basic mechanism of uridine insertion/deletion RNA editing in mitochondria of kinetoplastid protists has been established for some time but the molecular details remained largely unknown. Recently, there has been significant progress in defining the molecular components of the editing reaction. A number of factors have been isolated from trypanosome mitochondria, some of which have been definitely implicated in the uridine insertion/deletion RNA editing reaction and others of which have been circumstantially implicated. Several protein complexes have been isolated which exhibit some editing activities, and the macromolecular organization of these complexes is being analyzed. In addition, there have been several important technical advances in the in vitro analysis of editing. In this review we critically examine the various factors and complexes proposed to be involved in RNA editing.

Indexed as

RNA EditingAnimalsEndonucleasesExonucleasesMitochondriaProtozoan ProteinsRNA-Binding ProteinsRNA HelicasesRNA Ligase (ATP)TrypanosomaUridineEndonucleasesExonucleasesgBP21 protein, Trypanosoma bruceiProtozoan ProteinsRBP16 protein, TrypanosomaREAP-1 protein, Trypanosoma bruceiRNA-Binding ProteinsRNA HelicasesRNA Ligase (ATP)TBRGG1 protein, Trypanosoma bruceiUridine

Identifiers

PMID12591999
PMCPMC1370392
OpenAlexW2153641622

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.