ArticleThe Journal of experimental medicine2003
A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 82 citations in OpenAlex.
- Extracellular Vesicles-mediated recombinant IL-10 protects against ascending infection-associated preterm birth by reducing fetal inflammatory response.Frontiers in immunology · 2023Article
- RNA mFrontiers in immunology · 2022Review
- SOCS3 Expression by Thymic Stromal Cells Is Required for Normal T Cell Development.Frontiers in immunology · 2021Article
- Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients.Cellular & molecular immunology · 2019Article
- mNature · 2017Article
- A missense mutation in zbtb17 blocks the earliest steps of T cell differentiation in zebrafish.Scientific reports · 2017Article
- Methylation and microRNA-mediated epigenetic regulation of SOCS3.Molecular biology reports · 2015Article
- Immunohistochemical analysis of IL-6, IL-8/CXCR2 axis, Tyr p-STAT-3, and SOCS-3 in lymph nodes from patients with chronic lymphocytic leukemia: correlation between microvascular characteristics and prognostic significance.BioMed research international · 2014Article
- The role of suppressors of cytokine signalling in human neoplasms.Molecular biology international · 2014Review
- SOCS3 deletion in T lymphocytes suppresses development of chronic ocular inflammation via upregulation of CTLA-4 and expansion of regulatory T cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- SOCS3: An essential physiological inhibitor of signaling by interleukin-6 and G-CSF family cytokines.JAK-STAT · 2013Review
- Expression of SOCS1 and SOCS3 genes in human graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.Blood research · 2013Article
- SOCS proteins in development and disease.American journal of clinical and experimental immunology · 2013Article
- Novel IL27p28/IL12p40 cytokine suppressed experimental autoimmune uveitis by inhibiting autoreactive Th1/Th17 cells and promoting expansion of regulatory T cells.The Journal of biological chemistry · 2012Article
- The biology and mechanism of action of suppressor of cytokine signaling 3.Growth factors (Chur, Switzerland) · 2012Review
- Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10.Immunology · 2011Article
- Suppressors of cytokine signaling 3 expression in eosinophils: regulation by PGE₂ and Th2 cytokines.Clinical & developmental immunology · 2011Article
- Gene expression profiling in lungs of chronic asthmatic mice treated with galectin-3: downregulation of inflammatory and regulatory genes.Mediators of inflammation · 2011Article
- Interleukin-2 inhibits polarization to T helper type 1 cells and prevents mouse acute graft-versus-host disease through up-regulating suppressors of cytokine signalling-3 expression of naive CD4+ T cells.Clinical and experimental immunology · 2010Article
- A pivotal role for interleukin-27 in CD8+ T cell functions and generation of cytotoxic T lymphocytes.Journal of biomedicine & biotechnology · 2010Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Suppressor of cytokine signaling (SOCS)3 has been characterized as a negative feedback regulator in cytokine-mediated Janus kinase signal transducer and activator of transcription signaling. However, this study shows that T cells from transgenic mice expressing SOCS3 exhibit a significant reduction in interleukin (IL)-2 production induced by T cell receptor cross-linking when T cells are costimulated with CD28. Decreased protein expression in SOCS3(+/-) mice enhanced CD28-mediated IL-2 production, clearly indicating the correlation between expression level of SOCS3 and IL-2 production ability. The SOCS3 protein interacted with phosphorylated CD28 through its SH2 domain but not the kinase inhibitory region. In addition, a point mutation in the SOCS3 SH2 domain attenuated the inhibition of CD28 function in IL-2 promoter activation. Committed T helper (Th)2 cells exclusively expressed SOCS3 and production of Th2 cytokines, such as IL-4 and IL-5, was much less dependent on CD28 costimulation compared with interferon gamma and IL-2 production in Th1 cells. Consistent with this notion, the expression level of SOCS3 in early T cell activation influenced the ability of IL-2 production induced by CD28 costimulation. Therefore, the SOCS3 may play an alternative role in prohibiting excessive progression of CD28-mediated IL-2 production.
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